PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root

Proceedings of the National Academy of Sciences of the United States of America
Kun YueIve De Smet

Abstract

In plants, the generation of new cell types and tissues depends on coordinated and oriented formative cell divisions. The plasma membrane-localized receptor kinase ARABIDOPSIS CRINKLY 4 (ACR4) is part of a mechanism controlling formative cell divisions in the Arabidopsis root. Despite its important role in plant development, very little is known about the molecular mechanism with which ACR4 is affiliated and its network of interactions. Here, we used various complementary proteomic approaches to identify ACR4-interacting protein candidates that are likely regulators of formative cell divisions and that could pave the way to unraveling the molecular basis behind ACR4-mediated signaling. We identified PROTEIN PHOSPHATASE 2A-3 (PP2A-3), a catalytic subunit of PP2A holoenzymes, as a previously unidentified regulator of formative cell divisions and as one of the first described substrates of ACR4. Our in vitro data argue for the existence of a tight posttranslational regulation in the associated biochemical network through reciprocal regulation between ACR4 and PP2A-3 at the phosphorylation level.

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Citations

Apr 16, 2016·Trends in Plant Science·Barbara Berckmans, Rüdiger Simon
May 22, 2016·Journal of Experimental Botany·Nathan CzyzewiczIve De Smet
Jul 13, 2016·Trends in Plant Science·Crisanto Gutierrez
Nov 5, 2016·Plant Molecular Biology·María Noelia Muñiz GarcíaDaniela Andrea Capiati
Apr 28, 2018·Journal of Experimental Botany·Natalia NikonorovaIve De Smet
Nov 29, 2016·The New Phytologist·María Fernández-MarcosCrisanto Gutierrez
Dec 10, 2021·Omics : a Journal of Integrative Biology·Pratigya Subba, Thottethodi Subrahmanya Keshava Prasad

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