PP2A fulfills its promises as tumor suppressor: which subunits are important?

Cancer Cell
Christine Van Hoof, Jozef Goris

Abstract

Reversible phosphorylation of proteins, catalyzed by kinases and phosphatases, is a key regulatory mechanism in the control of multiple cellular signal transduction pathways. Uncontrolled regulation by the altered phosphorylation state of the components of these pathways often leads to increased cell proliferation and cell transformation. Many viruses encode oncogenic proteins, required for their efficient viral replication, which deregulate the activity of host cell proteins. This might program cells to a malignant state, underlying the molecular mechanism of tumor formation and cancer development. Recent studies reveal a role for a specific form of protein phosphatase 2A (PP2A) in viral-induced cell transformation by interaction with the small t antigen (ST) of the DNA tumor simian virus 40 (SV40).

References

Dec 15, 2011·The Journal of Biological Chemistry·Deivid L S MigueletiNilson I T Zanchin
Nov 10, 2007·Molecular and Cellular Biology·Alessandra MagentaFabio Martelli
Feb 26, 2010·American Journal of Physiology. Renal Physiology·I Alexandru BobulescuOrson W Moe
Oct 15, 2005·The Journal of Clinical Investigation·Christina G KatsiariGeorge C Tsokos
Aug 28, 2009·International Journal of Cancer. Journal International Du Cancer·Ali NaderiIan C Bennett
Nov 21, 2007·Journal of Cellular Physiology·Kamel KhaliliMahmut Safak
Jan 22, 2005·Current Opinion in Genetics & Development·Veerle JanssensChristine Van Hoof
Apr 23, 2005·Cell Death and Differentiation·D PerrottiP Neviani
Jun 10, 2008·The Journal of Biological Chemistry·Claudia FilaPeter van der Sluijs
Aug 30, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Laurent SchwartzPhilippe Chaumet-Riffaud

Related Concepts

Biochemical Pathway
Tumor Suppressor Genes
Phosphoric Monoester Hydrolases
Phosphatidylinositol 3-Kinases
Metastasis Suppressor Genes
Telomerase Catalytic Subunit
Simian virus 40
Virus Replication
Protein Phosphorylation
Signal Transduction Pathways

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

© 2020 Meta ULC. All rights reserved