PPAR-γ in innate and adaptive lung immunity

Journal of Leukocyte Biology
Samuel Philip Nobs, Manfred Kopf

Abstract

The transcription factor PPAR-γ (peroxisome proliferator-activated receptor-γ) is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. It is strictly required for the generation of alveolar macrophages by controlling differentiation of fetal lung monocyte precursors. Furthermore, it plays an important role in lung allergic inflammation by licensing lung dendritic cell t helper 2 (Th2) priming capacity as well as acting as a master transcription factor for pathogenic Th2 cells. Due to this plethora of functions and its involvement in multiple pulmonary diseases including asthma and pulmonary alveolar proteinosis, understanding the role of PPAR-γ in lung immunity is an important subject of ongoing research.

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Citations

Oct 15, 2019·Frontiers in Immunology·Leonhard von MeyennChristoph Schlapbach
May 13, 2020·PPAR Research·Oxana Yu KytikovaTatyana A Gvozdenko
May 14, 2020·Cancers·Sue Chin LeeGábor J Tigyi
Jan 27, 2019·Nature Reviews. Immunology·David G RussellBrian C VanderVen
Feb 26, 2019·Mediators of Inflammation·Longgui NingGuoqiang Xu
Nov 5, 2019·Frontiers in Immunology·Nick P GoplenJie Sun
Nov 5, 2019·Frontiers in Immunology·Jayne Louise WilsonThomas Weichhart
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Liwei WuJianye Wu
Jun 11, 2020·Annual Review of Nutrition·Samuel Philip NobsEran Elinav
Feb 13, 2021·Frontiers in Immunology·Drishti Tiwari, Pawan Gupta
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Seung-Jae KimGye Young Park
Jun 1, 2021·Journal, Genetic Engineering & Biotechnology·Antoine Fakhry AbdelMassihBiagio Castaldi
Jul 1, 2021·EClinicalMedicine·Mariano DuarteRodolfo P Rothlin

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