PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection.

Journal of Virology
Su HuangJ Sun

Abstract

Alveolar macrophages (AM) play pivotal roles in modulating host defense, pulmonary inflammation, and tissue injury following respiratory viral infections. However, the transcriptional regulation of AM function during respiratory viral infections is still largely undefined. Here we have screened the expression of 84 transcription factors in AM in response to influenza A virus (IAV) infection. We found that the transcription factor PPAR-γ was downregulated following IAV infection in AM through type I interferon (IFN)-dependent signaling. PPAR-γ expression in AM was critical for the suppression of exaggerated antiviral and inflammatory responses of AM following IAV and respiratory syncytial virus (RSV) infections. Myeloid PPAR-γ deficiency resulted in enhanced host morbidity and increased pulmonary inflammation following both IAV and RSV infections, suggesting that macrophage PPAR-γ is vital for restricting severe host disease development. Using approaches to selectively deplete recruiting monocytes, we demonstrate that PPAR-γ expression in resident AM is likely important in regulating host disease development. Furthermore, we show that PPAR-γ was critical for the expression of wound healing genes in AM. As such, myeloid PPAR-γ de...Continue Reading

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Citations

May 27, 2020·Journal of Cellular Physiology·Xiao-Qin LuoCha-Xiang Guan
Nov 5, 2019·Frontiers in Immunology·Nick P GoplenJie Sun
Oct 16, 2019·Journal of Immunology Research·Prem P Lamichhane, Amali E Samarasinghe
Jul 18, 2020·Viruses·Gaurav Malik, Yan Zhou
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Nov 3, 2020·Frontiers in Molecular Biosciences·Francesca PagliariLuca Tirinato
Jan 21, 2021·International Journal of Molecular Sciences·Márcia V de CarvalhoAdriana R Silva
Feb 13, 2021·Frontiers in Immunology·Drishti Tiwari, Pawan Gupta
Dec 22, 2020·Cytokine & Growth Factor Reviews·Marina DukhinovaAnna Shtro
Aug 18, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Merilin Al Sharif
Nov 27, 2021·Expert Reviews in Molecular Medicine·Pamelia N LimAlissa C Rothchild

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