PPAR-alpha Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration.

PPAR Research
Marisol Del V Cano, Peter L Gehlbach

Abstract

The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors. There are currently three known PPAR subtypes, alpha, beta, and gamma. The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD). These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and progression of "dry" AMD, and vascular endothelial growth factor (VEGF) mediated pathways that stimulate choroidal neovascularization (CNV), characteristic of "wet" AMD. PPAR-alpha is found in retina and also on vascular cells important to formation of CNV. At this time, however, relatively little is known about potential contributions of PPAR-alpha to the pathogenesis of dry and wet AMD. This review examines current literature for potential roles of PPAR-alpha in the pathogenesis and potential treatment of AMD with emphasis on prevention and treatment of wet AMD.

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Citations

Feb 23, 2013·PPAR Research·Andreea CiudinRafael Simó
Jan 6, 2017·Oxidative Medicine and Cellular Longevity·Yuhei Nishimura, Hideaki Hara
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Arunodoy SurHerbert Weissbach
Nov 5, 2020·Npj Aging and Mechanisms of Disease·Ashok MandalaJaya P Gnana-Prakasam
Dec 10, 2020·International Journal of Molecular Sciences·Xiaozheng Dou, Adam S Duerfeldt
Dec 11, 2020·Npj Aging and Mechanisms of Disease·Ashok MandalaJaya P Gnana-Prakasam

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Methods Mentioned

BETA
immunoprecipitation

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