PPARβ/δ and lipid metabolism in the heart

Biochimica Et Biophysica Acta
Xavier PalomerManuel Vázquez-Carrera

Abstract

Cardiac lipid metabolism is the focus of attention due to its involvement in the development of cardiac disorders. Both a reduction and an increase in fatty acid utilization make the heart more prone to the development of lipotoxic cardiac dysfunction. The ligand-activated transcription factor peroxisome proliferator-activated receptor (PPAR)β/δ modulates different aspects of cardiac fatty acid metabolism, and targeting this nuclear receptor can improve heart diseases caused by altered fatty acid metabolism. In addition, PPARβ/δ regulates glucose metabolism, the cardiac levels of endogenous antioxidants, mitochondrial biogenesis, cardiomyocyte apoptosis, the insulin signaling pathway and lipid-induced myocardial inflammatory responses. As a result, PPARβ/δ ligands can improve cardiac function and ameliorate the pathological progression of cardiac hypertrophy, heart failure, cardiac oxidative damage, ischemia-reperfusion injury, lipotoxic cardiac dysfunction and lipid-induced cardiac inflammation. Most of these findings have been observed in preclinical studies and it remains to be established to what extent these intriguing observations can be translated into clinical practice. This article is part of a Special Issue entitled: ...Continue Reading

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May 22, 2016·Biochimica Et Biophysica Acta·Gary D Lopaschuk
Nov 8, 2017·The Journal of Endocrinology·Cristina MoraAntonio Andrés
Dec 24, 2018·Journal of Cellular Physiology·Si ZhangLixiang Xue
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May 24, 2018·Heart Failure Reviews·Liang ChenShengshou Hu
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Aug 30, 2021·European Journal of Pharmacology·Mingyan ShaoYong Wang

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