PPARα contributes to colonic protection in mice with DSS-induced colitis

International Immunopharmacology
Yasu-Taka AzumaTadayoshi Takeuchi

Abstract

Inflammatory bowel disease (IBD) is characterized by repeated chronic inflammation of the gastrointestinal tract. We have used the complementary model of colonic inflammation to examine the roles of peroxisome proliferator-activated receptor α (PPARα) in colonic inflammation and thus its possible role in IBD. We characterized an innate immune-mediated model of colitis induced by dextran sulfate sodium (DSS). Mice with DSS-induced colitis were injected with Wy-14643 (2 mg/kg) as a PPARα agonist every day from day 0 to day 5. We show that mice given Wy-14643 were less susceptible to experimental acute colitis induced by DSS, and this decreased susceptibility was correlated with decreased production of IFNγ, IL-1β, IL-6, and TNF-α. Our findings suggest that PPARα has a role in controlling colonic inflammation and mucosal tissue homeostasis.

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Citations

Mar 3, 2012·Molecules and Cells·Je-Min Choi, Alfred L M Bothwell
Aug 30, 2011·The Journal of Veterinary Medical Science·Yuka FujimotoTadayoshi Takeuchi
Aug 27, 2013·PloS One·Sabina A MirRichard Kellermayer
Jul 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong Ki Park, Hye-Jin Park
Feb 16, 2016·Journal of Nutritional Science and Vitaminology·Yasuki HigashimuraToshikazu Yoshikawa
Jan 21, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y T AzumaT Takeuchi
Oct 20, 2015·International Immunopharmacology·Yukiko MatsuoTadayoshi Takeuchi
Oct 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y T AzumaT Takeuchi
Sep 11, 2014·British Journal of Pharmacology·Francesca BorrelliAngelo A Izzo
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Philippe Gervois, Roxane M Mansouri
Jul 15, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Kazuhiro NishiyamaTadayoshi Takeuchi
May 23, 2012·Trends in Pharmacological Sciences·Jie ChengFrank J Gonzalez
Nov 30, 2016·Clinics and Research in Hepatology and Gastroenterology·Man-Yi Sun, Jing-Na Lin
Dec 9, 2016·The Journal of Veterinary Medical Science·Kazuhiro NishiyamaTadayoshi Takeuchi
May 20, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jun ZhangHaiping Hao
Jul 19, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yunpeng QiFrank J Gonzalez
Feb 2, 2018·Biological & Pharmaceutical Bulletin·Yasuyuki FujimotoYasu-Taka Azuma
Feb 26, 2020·Histochemistry and Cell Biology·Agnese StanzaniRoberto Chiocchetti
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indumathi ManoharanSanthakumar Manicassamy
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao ZhangNanping Wang
Feb 19, 2019·Gastroenterology Research and Practice·Arash AssadsangabiAlan Lobo
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fan HongYonggong Zhai
Jun 9, 2018·Histochemistry and Cell Biology·Giorgia GaliazzoRoberto Chiocchetti
Sep 15, 2020·Frontiers in Pharmacology·Shinsuke OtagiriNaoya Sakamoto
Dec 13, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Yasuyuki FujimotoTadayoshi Takeuchi
Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adriano LamaMaria Beatrice Passani
Aug 22, 2021·Journal of Equine Veterinary Science·Giorgia GaliazzoRoberto Chiocchetti
Aug 27, 2021·Frontiers in Immunology·Paulo José BassoCristina Ribeiro de Barros Cardoso

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