PPARalpha gene variation and physical performance in Russian athletes

European Journal of Applied Physiology
Ildus I AhmetovViktor A Rogozkin

Abstract

Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARalpha intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARalpha intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P<0.0001) different compared to controls (70.0%). To examine the association between PPARalpha gene variant and fiber type composition, muscle biopsies from m. vastus lat...Continue Reading

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Citations

Sep 18, 2012·The Journal of Physiological Sciences : JPS·Ildus I AhmetovVictor A Rogozkin
May 18, 2013·Sports Medicine·Nir EynonDavid J Bishop
Aug 27, 2011·Journal of Sports Sciences·David C HughesAlun G Williams
May 2, 2013·British Journal of Sports Medicine·Yannis PitsiladisAlejandro Lucia
Sep 20, 2011·Sports Medicine·Zudin PuthuchearyHugh E Montgomery
May 5, 2011·The Journal of Physiology·Nir EynonAlejandro Lucia
Sep 29, 2007·The Journal of Physiology·Alun G Williams, Jonathan P Folland
Dec 1, 2010·The Veterinary Journal·Wiebke SchröderOttmar Distl
Jul 14, 2010·Journal of Science and Medicine in Sport·Agnieszka MaciejewskaPaweł Cięszczyk
May 9, 2009·Scandinavian Journal of Medicine & Science in Sports·N EynonJ Oliveira
Jan 22, 2014·European Journal of Sport Science·Valentina GinevicieneVaidutis Kucinskas
May 3, 2014·Journal of Sports Sciences·Emiliya S EgorovaIldus I Ahmetov
Nov 25, 2016·Scandinavian Journal of Medicine & Science in Sports·H ZempoH Murakami
Mar 2, 2013·Asia-Pacific Journal of Public Health·Chang-Duk HaHyun-Sik Kang
May 1, 2007·Medicine and Science in Sports and Exercise·Andrea PapariniVincenzo Romano-Spica
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Aug 28, 2020·Frontiers in Genetics·Rocio de la IglesiaAna Ramirez-de Molina
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Mar 30, 2017·Drug Testing and Analysis·Tessa WilkinNatasha Hamilton

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