Abstract
The PPARD polymorphisms were shown to be associated with circulating lipoprotein metabolism in various diseases. We aimed to check the contribution of PPARD rs2016520 and lipid concentration to the risk of intracerebral hemorrhages (ICH) and brain tumors (BT) in Han Chinese. A total of 864 participants were included in the case-control study. The melting temperature shift (Tm-shift) method was used for rs2016520 genotyping. Under the recessive model, PPARD rs2016520 was shown to be associated with the risk of ICH (P=0.029, odds ratio (OR)=2.72), specifically in males (P=0.045, OR=3.98). Additionally, we also found that the levels of TC and LDL-C were significantly higher in participants with brain diseases than in the controls (TC: P<0.0001; LDL-C: P<0.0001). Significantly higher HDL-C and lower ApoA-I levels were observed in the male patients with brain diseases (HDL-C: P<0.0001; ApoA-I: P=0.008), in contrast of a higher TG level in female ICH (P=0.023). Subsequent interaction analysis between PPARD rs2016520 and lipoprotein metabolism showed that the LDL-C level was positively correlated with ICH in the rs2016520-AA carriers (P<0.0001), but not in the other genotype carriers (AG or GG, P=0.300). Our results showed that PPARD ...Continue Reading
References
Dec 3, 2003·Journal of Internal Medicine·J SkogsbergUNKNOWN West of Scotland Coronary Prevention Study
Oct 14, 2006·Current Treatment Options in Cardiovascular Medicine·William L Isley
Apr 14, 2007·Diabetologia·N GrarupO Pedersen
Sep 1, 2007·Stroke; a Journal of Cerebral Circulation·Jared D SturgeonMary Cushman
Sep 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Jonathan C K Wells
Feb 9, 2008·Hypertension·Ondrej SedaPavel Hamet
May 12, 2009·Lancet·Adnan I QureshiDaniel F Hanley
Apr 7, 2010·Nature Genetics·Katsuhito YasunoMurat Günel
Jun 1, 2010·Heart and Vessels·Alexey G NikitinValery V Nosikov
Dec 24, 2010·Lipids in Health and Disease·Lin MiaoWei-Xiong Lin
Aug 20, 2011·PLoS Genetics·Kirstin MittelstrassThomas Illig
Jun 19, 2012·Thrombosis Research·Jianqing ZhouShiwei Duan
Oct 31, 2012·International Journal of Molecular Sciences·Rui-Xing YinMeng Li
Mar 21, 2013·Journal of Molecular Neuroscience : MN·Khouloud ChehaibiMohamed Naceur Slimane
Mar 28, 2013·Gene·Yi HuangShiwei Duan
Apr 5, 2013·PloS One·Danjie JiangShiwei Duan
Jun 4, 2013·Brain Research Bulletin·Samuel Henrique Vieira OliveiraLuciana Moreira Lima
Jul 17, 2013·Neurology·Chung-Fen TsaiCathie L M Sudlow
Aug 29, 2013·Endocrine·Rui-hua ChenXiao-zhen Jiang
May 7, 2014·PloS One·José Medina-EcheverzPedro Berraondo
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kalyani RajuLee Jun Kai
Jun 6, 2014·Nature·Joshua FinkelsteinUrsula Weiss
Jun 6, 2014·The Oncologist·Charles J VechtAlberto Duran-Pena
Citations
Apr 16, 2016·Neuroscience Letters·Zhepei WangXiang Gao
Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jikuang ZhaoYi Huang
Mar 28, 2017·DNA and Cell Biology·Shengjun ZhouYi Huang
Feb 16, 2017·Parasitology Research·Weida PanGuoqing Li
Jun 5, 2018·BioMed Research International·Yeqi FuGuoqing Li
Mar 7, 2019·The Korean Journal of Parasitology·Yeqi FuGuoqing Li
Mar 22, 2020·Scientific Reports·Xiaoying DingYa Gao