PPARG2 Pro12Ala polymorphism influences body composition changes in severely obese patients consuming extra virgin olive oil: a randomized clinical trial

Nutrition & Metabolism
Ana Paula Santos RodriguesErika Aparecida Silveira

Abstract

Previous intervention studies have reported the association of the PPARG2 Pro12Ala (rs1801282) and IL6 -174G > C (rs1800795) polymorphisms with weight loss; however, their results are inconsistent. We aimed to investigate the effect of the PPARG2 Pro12Ala and IL6 -174G > C polymorphisms on body weight, body composition and metabolic parameters after a 12-week nutritional intervention with a traditional Brazilian diet and extra virgin olive oil supplementation in severely obese patients. A total of 149 severely obese individuals [body mass index (BMI) ≥ 35 kg/m2] were randomized into three 12-week nutritional intervention groups - the extra virgin olive oil supplementation (OO) group (n = 50), the traditional Brazilian diet (DieTBra) group (n = 49), and the DieTBra plus extra virgin olive oil supplementation (DieTBra+OO) group (n = 50). Anthropometric measurements, body composition, metabolic parameters, physical activity practise and dietary intake were assessed. The associations were tested using generalized linear models adjusted for confounders. The PPARG2 Pro12Ala polymorphism influenced body composition changes. Ala carriers in the intervention groups with extra virgin olive oil supplementation had greater reductions in th...Continue Reading

Associated Clinical Trials

References

Jul 1, 1988·Journal of Biological Standardization·A F Bristow, R E Das
Apr 5, 2000·The Journal of Biological Chemistry·C F TerryF R Green
Mar 15, 2001·Diabetes·J LuanN J Wareham
Jul 30, 2003·Cadernos de saúde pública·Rosely SichieriAn bal Sanchez Moura
Nov 28, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Demosthenes B PanagiotakosChristodoulos Stefanadis
Aug 12, 2008·The American Journal of Clinical Nutrition·Alanna J MoshfeghLinda E Cleveland
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J López-MirandaN Yiannakouris
Apr 28, 2010·The British Journal of Nutrition·Diana Barbosa CunhaRosangela Alves Pereira
May 4, 2010·World Review of Nutrition and Dietetics·Amelia MartiJ Alfredo Martínez
Oct 12, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J NaukkarinenK H Pietiläinen
Mar 21, 2012·The Proceedings of the Nutrition Society·Fátima Pérez de HerediaAscensión Marcos
Jun 5, 2012·Progress in Molecular Biology and Translational Science·Iwona Rudkowska, Louis Pérusse
Jul 4, 2012·Circulation·James O HillJohn C Peters
Jul 18, 2012·PLoS Medicine·Carlos A Monteiro, Geoffrey Cannon
Sep 18, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lidia SantarpiaFabrizio Pasanisi
Mar 27, 2013·Nature Reviews. Endocrinology·Julia S El-Sayed Moustafa, Philippe Froguel
Jun 3, 2014·Medicine and Science in Sports and Exercise·Maria HildebrandUlf Ekelund
Oct 25, 2014·Current Atherosclerosis Reports·Emanuela Lapice, Olga Vaccaro
Nov 2, 2014·International Journal of Epidemiology·Inácio Cm da SilvaPedro C Hallal
Jan 17, 2015·Advances in Nutrition·Ambika SatijaFrank B Hu
May 6, 2015·Progress in Cardiovascular Diseases·Miguel A Martínez-GonzálezUNKNOWN PREDIMED INVESTIGATORS
Sep 2, 2016·BioFactors·Marta PiroddiFrancesco Galli

❮ Previous
Next ❯

Citations

Jul 2, 2019·Endocrine Research·Raquel Andrade de SiqueiraErika Aparecida Silveira
Jul 2, 2020·The Korean Journal of Pain·Carolina Rodrigues MendonçaErika Aparecida Silveira
Aug 11, 2020·Archives of public health = Archives belges de santé publique·Erika Aparecida SilveiraMatias Noll
Jun 26, 2020·International Journal of Environmental Research and Public Health·Carolina Rodrigues MendonçaErika Aparecida Silveira
May 20, 2020·Nutrients·Annelisa Silva E Alves de Carvalho SantosErika Aparecida Silveira
Jun 6, 2020·International Journal of Environmental Research and Public Health·Erika Aparecida SilveiraMatias Noll
Dec 4, 2019·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Annelisa S A C SantosErika A Silveira

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
genotyping
electrophoresis

Clinical Trials Mentioned

NCT02463435

Software Mentioned

STATA
EpiData
DieTBra
ActiLife
MedDiet
R package GGIR
ENMO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.