PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in cats

Stroke; a Journal of Cerebral Circulation
H TakahashiR J Traystman

Abstract

We tested the hypothesis that administration of 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), a potent sigma-receptor ligand, during transient focal ischemia would affect early postischemic brain injury. Halothane-anesthetized cats underwent left middle cerebral artery occlusion for 90 minutes followed by 4 hours of reperfusion. Control cats received saline (n = 10). Experimental cats (2 groups, n = 10 per group) were treated with PPBP at a rate of 0.1 mumol/kg per hour (PPBP-0.1) or administered 1 mumol/kg per hour (PPBP-1) intravenously from 75 minutes after initiation of ischemia and continuing during the 4 hours of reperfusion. As measured by the microsphere method, blood flow to the ipsilateral caudate nucleus was decreased similarly in all groups during ischemia. Blood flow to the ipsilateral inferior temporal cortex was decreased during ischemia in all groups but was higher in cats subsequently treated with PPBP at the highest dose, even before drug administration. There was no difference in blood flow to the ipsilateral caudate nucleus or inferior temporal cortex (area of greatest cortical injury) during reperfusion. Triphenyltetrazolium-determined injury volume of the ipsilateral cerebral hemisphere (control, 29 +/- 5%...Continue Reading

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Citations

Mar 26, 2003·ILAR Journal·Richard J Traystman
Aug 1, 1997·Anesthesia and Analgesia·H TakahashiJ R Kirsch
Jul 25, 2006·Anesthesia and Analgesia·Kamila VagnerovaJeffrey R Kirsch
Apr 26, 2007·Anesthesia and Analgesia·Sufang YangJeffrey R Kirsch
Jun 22, 2010·Translational Stroke Research·Christopher C LeonardoKeith R Pennypacker
Oct 16, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhen LiLing Chen
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A BhardwajR J Traystman
Oct 9, 2007·Brain Research·John A SchetzJames W Simpkins
Jul 1, 1997·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R L Martin
Feb 24, 2015·Journal of Pharmacological Sciences·Linda NguyenRae R Matsumoto
Feb 24, 2015·Journal of Pharmacological Sciences·Karsten Ruscher, Tadeusz Wieloch
Aug 29, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Raymond C KoehlerLee J Martin
Feb 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Cheng-Wei LuSu-Jane Wang

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