PPIA is a novel adipogenic factor implicated in obesity

Obesity
Lihong ZhangYun Bai

Abstract

To assess the role of peptidyl-prolyl cis/trans isomerase a (PPIA) in adipogenesis and obesity. Fat mass and adipocyte sizes of PPIA-/- and wild-type mice were compared. The role of PPIA in adipocyte differentiation of 3T3L1 and MEFs cells was analyzed by gene silencing and overexpression. The roles of PPIA in obesity were observed on a high-fat diet obesity model and a gestational diabetes obesity model. PPIA-/- mice had significantly less fat than PPIA+/+ mice. The adipocyte size of PPIA-/- mice was significantly smaller than wild type. Silencing PPIA in 3T3L1 cells significantly impaired its adipocyte differentiation ability. Similarly, MEFs from PPIA-/- mice differentiated less than wild type, while their differentiation ability was restored by PPIA overexpression. PPIA-silenced 3T3L1 cells had significantly lower expression of PPARG, C/EBPA, and C/EBPB at late stage of adipocyte differentiation, which was the same in PPIA-/- MEFs. When fed a high-fat diet, PPIA-/- mice gained significantly less weight than wild type, accompanied by reduced PPARG, C/EBPA, and C/EBPB expression. PPIA expression was significantly higher in adipose tissue of gestational diabetes rat offspring, which had higher inguinal fat/body weight ratios t...Continue Reading

References

Nov 2, 1984·Science·R E HandschumacherD W Speicher
Nov 7, 1998·The Journal of Biological Chemistry·G J DarlingtonO A MacDougald
Jul 23, 2003·Current Topics in Medicinal Chemistry·Jacqueline DornanMalcolm D Walkinshaw
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Jörg Fanghänel, Gunter Fischer
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Evan D Rosen
Jul 7, 2005·Genome Biology·Ping Wang, Joseph Heitman
Jan 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A YessoufouN A Khan
Aug 7, 2007·Biochemical and Biophysical Research Communications·Huirong YangLong Yu
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
Dec 22, 2010·The Journal of Experimental Medicine·Patrizia NigroBradford C Berk
Feb 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimio SatohBradford C Berk
Jun 15, 2011·The Journal of Biological Chemistry·Zhaoliang FeiIra Pastan
Oct 18, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·David DilworthChristopher J Nelson
Jan 10, 2012·The Journal of Nutritional Biochemistry·Ousseynou SarrFlorence Gondret
May 25, 2012·Nature·Robert D BellBerislav V Zlokovic
Jul 21, 2012·Biochemical and Biophysical Research Communications·Daijun ZhouHaiyang He
Nov 28, 2012·Clinics in Liver Disease·Fernando E MembrenoEric J Lawitz
Nov 2, 2013·Cell Death & Disease·P NigroM C Capogrossi
Feb 18, 2014·Biochimica Et Biophysica Acta·Steven D Hanes
Mar 26, 2014·Current Diabetes Reports·Abigail Fraser, Debbie A Lawlor
May 8, 2014·Journal of Obesity·Kristine MatusiakMarloes Dekker Nitert
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Carlo CamilloniMichele Vendruscolo
Dec 3, 2014·Biochimica Et Biophysica Acta·Steven D Hanes

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Citations

Aug 24, 2018·Molecular & Cellular Proteomics : MCP·Asrar Ali KhanMarcel Scheideler
May 18, 2019·International Journal of Molecular Sciences·Erica RuraliPatrizia Nigro
Dec 24, 2019·Expert Opinion on Investigational Drugs·Daren R UreRobert T Foster

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