PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription.

Genes & Development
David B BeckDanny Reinberg

Abstract

Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.

References

Sep 26, 2001·The Journal of Biological Chemistry·S BurmaD J Chen
Mar 18, 2003·Molecular and Cellular Biology·Irene M WardJunjie Chen
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael M Vilenchik, Alfred G Knudson
Jan 28, 2004·Cell·Charles J Sherr
May 18, 2004·Genes & Development·Gunnar SchottaThomas Jenuwein
Oct 23, 2004·Science·UNKNOWN ENCODE Project Consortium
Nov 5, 2004·Nature·Yentram HuyenThanos D Halazonetis
Jun 4, 2005·Genes & Development·Bing XiaoJonathan R Wilson
Jun 4, 2005·Genes & Development·Jean-François CoutureRaymond C Trievel
Dec 20, 2005·Nature Cell Biology·Emily E Arias, Johannes C Walter
Jan 24, 2006·Molecular and Cellular Biology·Masayoshi IizukaM Mitchell Smith
Feb 14, 2006·Science·Michael Shogren-KnaakCraig L Peterson
Oct 13, 2006·Molecular and Cellular Biology·Christopher R VakocGerd A Blobel
Mar 9, 2007·Genes & Development·Emily E Arias, Johannes C Walter
Jun 2, 2007·Cell·Patrick TrojerDanny Reinberg
Aug 21, 2007·Molecular Cell·Xiaobing ShiOr Gozani
Oct 31, 2007·Molecular and Cellular Biology·James J PesaventoCraig A Mizzen
Nov 17, 2007·Science·Nadine K KolasDaniel Durocher
Dec 26, 2007·The Journal of Cell Biology·Mathieu TardatEric Julien
Jan 2, 2008·The Journal of Cell Biology·Stine JørgensenClaus Storgaard Sørensen
May 27, 2008·Nature Reviews. Cancer·David Frescas, Michele Pagano
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Noah DephoureSteven P Gygi
Sep 17, 2008·Nature Structural & Molecular Biology·Xu LuKarolin Luger
Oct 2, 2008·The Journal of Biological Chemistry·Nikole T GreesonSteven L Sanders

❮ Previous
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Citations

Sep 3, 2013·Quarterly Reviews of Biophysics·Zhanxin Wang, Dinshaw J Patel
Jan 25, 2013·Nucleic Acids Research·Stine JørgensenClaus Storgaard Sørensen
Nov 16, 2012·Genes & Development·David B BeckDanny Reinberg
May 13, 2014·Cell and Tissue Research·Detlef Doenecke
Feb 12, 2015·Developmental Cell·Daniel J McKayA Gregory Matera
Feb 26, 2016·Stem Cell Reports·Xin GaoEmery H Bresnick
Sep 3, 2013·Mutation Research·Michael J Hendzel, Roger A Greenberg
Dec 29, 2015·Biochemical and Biophysical Research Communications·Jun ZhangRan Wang
Sep 5, 2012·Seminars in Cell & Developmental Biology·Michaela Frye, Salvador Aznar Benitah
Nov 20, 2014·Journal of Medicinal Chemistry·H Ümit KaniskanJian Jin
Mar 10, 2016·Journal of Molecular Biology·Taverekere S GirishSong Tan
Dec 17, 2015·Nature Communications·Zhiwei WangWenyi Wei
Oct 7, 2015·The Journal of Organic Chemistry·Egoitz CondeFernando P Cossío
Sep 8, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Yoko Hayashi-TakanakaHiroshi Kimura
Sep 24, 2015·Scientific Reports·Sara WeirichAlbert Jeltsch
Sep 5, 2015·Nucleic Acids Research·Sushmita RoyRupa Sridharan
Apr 2, 2014·Biochimica Et Biophysica Acta·Carlos RiveraAlejandra Loyola
Mar 19, 2014·Biochimica Et Biophysica Acta·Scott B Rothbart, Brian D Strahl
Apr 18, 2015·Clinical and Translational Medicine·William R SwindellJohann E Gudjonsson
Jul 27, 2015·Pharmacology & Therapeutics·Simone S RiedelKathrin M Bernt
Apr 14, 2016·Seminars in Cell & Developmental Biology·Stefan F Pinter
Sep 17, 2014·The FEBS Journal·Laia Bosch-Presegué, Alejandro Vaquero
Apr 16, 2016·Cancer Letters·Ben LiuKexin Chen
Jul 28, 2015·Nature Neuroscience·Jianxun WangMichael G Rosenfeld
Aug 11, 2015·Frontiers in Chemistry·Chunngai Hui, Tao Ye
May 12, 2015·Nature Chemical Biology·Baoxu PangJacques Neefjes
Apr 18, 2015·BMC Bioinformatics·Matthias HeinigFrank Johannes
Oct 2, 2012·Cell·Philipp VoigtDanny Reinberg
Dec 4, 2012·Molecular Cell·Joshua C BlackJohnathan R Whetstine
Jun 18, 2014·Biochemical and Biophysical Research Communications·Lushuai YaoYingli Sun
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew W DeVilbissEmery H Bresnick
Dec 31, 2014·The Journal of Cell Biology·Shrivatsav PattabiramanRabindranath De La Fuente

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