PMID: 8967286Jan 1, 1996Paper

Practicability, effectiveness and tolerance of a standardized prepared theophylline infusion

Acta medica Austriaca
W R PohlK P Pfeiffer

Abstract

The practicality, efficacy, and tolerance of a standardized, ready-to-use theophylline solution (Eloasthmin, Leopold Pharma, Graz) was studied on 33 patients with bronchial asthma and/or chronic obstructive bronchitis (COPD) (19 males, 14 females) aged 19 to 79 (median 50) years. Eloasthmin a ready-to-use pure theophylline solution containing no auxilliary substances, contains one gram theophyllin per liter in a hypotonic (2/3) NaCl solution. The infusion therapy was carried out in patients in an acute stage of their chronic obstructive ventilation dysfunction. The therapy was carried out for 2 to 4 days at a dose of 400 to 1000 mg theophylline per day, so that theophylline blood levels remained within the therapeutic range of 8 to 20 mg/ml. A highly significant improvement (p < 0.001) of lung function parameters was seen during treatment: VC before therapy = 2.46 l, after therapy = 3.36 l; FEV 1 before therapy = 1.34 l, after therapy = 2.04 l; and PEF before therapy = 3.48 l/s after therapy = 5.13 l/s. Since most patients also received concomittant medication (beta 2-sympathomimetica and/or glucocorticoids), it was difficult to differentiate the specific efficacy of the theophylline.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.