Practical and quality-control aspects of multi-element analysis with quadrupole ICP-MS with special attention to urine and whole blood

Analytical and Bioanalytical Chemistry
Jan L M De BoerWilbert Van Den Beld

Abstract

Two screening methods were developed for rapid analysis of a great number of urine and blood samples within the framework of an exposure check of the population after a firework explosion. A total of 56 elements was measured including major elements. Sample preparation consisted of simple dilution. Extensive quality controls were applied including element addition and the use of certified reference materials. Relevant results at levels similar to those found in the literature were obtained for Co, Ni, Cu, Zn, Sr, Cd, Sn, Sb, Ba, Tl, and Pb in urine and for the same elements except Ni, Sn, Sb, and Ba in blood. However, quadrupole ICP-MS has limitations, mainly related to spectral interferences, for the analysis of urine and blood, and these cause higher detection limits. The general aspects discussed in the paper give it wider applicability than just for analysis of blood and urine-it can for example be used in environmental analysis.

Citations

Jan 23, 2010·Biological Trace Element Research·Zbigniew SzybińskiHalina Mrowiec
Apr 14, 2006·Analytical and Bioanalytical Chemistry·Arabinda K DasMiguel de la Guardia
Jul 22, 2014·Drug Testing and Analysis·Oliver KrugMario Thevis
Jun 19, 2013·International Journal of Occupational Medicine and Environmental Health·Renata BrodzkaBeata Janasik
Aug 12, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yoshihiro SuzukiShoichiro Tsugane
Dec 15, 2006·Analytical Chemistry·Dijana JuresaKevin A Francesconi

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