PMID: 1911153Sep 1, 1991

Practical aspects in the use of cyclosporin in paediatric nephrology

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Peter F HoyerGisela Offner


Many factors must be considered for the effective and safe use of cyclosporin A (CsA) in paediatric nephrology. Detailed knowledge of the variable bioavailability, tissue distribution, and metabolism, as well as causes which lead to their alteration are necessary. Factors which affect the activity of the mixed function oxidase system cytochrome P-450 must be considered, i.e. liver dysfunction and many drugs. Precise knowledge of the CsA determination method and the spectrum of metabolites is essential. In children with renal transplants, a body surface area-related dose will better meet the dose requirements than a body weight related-dose. For drug level monitoring whole blood rather than plasma should be used, and the parent drug level should be the main determinant; elevated metabolite levels may be important in suspected nephrotoxicity or liver dysfunction. Pharmacokinetic profiles are necessary to discover absorption problems or increased CsA clearance rates which necessitate shorter dosing intervals. In children with steroid-dependent minimal change nephrotic syndrome, remission without steroids is maintained as long as CsA is given. The appropriate starting dosage is 150 mg/m2 per day; trough level monitoring is mandator...Continue Reading


Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Apr 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·H J SchlittR Pichlmayr
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S R AlexanderT E Nevins
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Mar 15, 1990·The New England Journal of Medicine·P F WhitingtonA L Baker
Apr 1, 1990·Molecular and Biochemical Parasitology·C B Poole, S A Williams
Jun 1, 1990·Acta paediatrica Scandinavica·Peter F HoyerR Pichlmayr
May 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P Niaudet
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R SchoumacherD A Spyker
Apr 27, 1985·Lancet·R D AllenP J Morris
Feb 8, 1986·Lancet·W B RossJ R Salaman
Apr 26, 1986·Lancet·J M Pochet, Y Pirson
Jun 14, 1986·Lancet·J M GriñoJ Alsina
Aug 30, 1986·Lancet·H H Neumayer, K Wagner
Sep 20, 1986·Lancet·C LagrueR Robeva
Jan 1, 1987·Transplantation·B M FreedN Lempert
Feb 1, 1988·Human Immunology·Adriana ZeeviR J Duquesnoy
Mar 1, 1988·Kidney International·Amir TejaniM R Khawar
Mar 15, 1986·British Medical Journal·D K JonesD J White
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F B Waldo, E C Kohaut
Jan 7, 1988·The New England Journal of Medicine·C V BroomeA W Hightower
Mar 1, 1988·Medical Toxicology and Adverse Drug Experience·J P Scott, T W Higenbottam
Jan 15, 1988·Klinische Wochenschrift·M J MihatschR Hällgren
Mar 1, 1986·Clinical Pharmacokinetics·R J PtachcinskiG J Burckart
May 1, 1986·British Journal of Clinical Pharmacology·H CarstensenH Dieperink
Oct 1, 1986·Clinical Pharmacology and Therapeutics·G C YeeH J Deeg
Jan 1, 1986·Springer Seminars in Immunopathology·P A Miescher
Sep 1, 1987·British Journal of Clinical Pharmacology·M Rowland, S K Gupta
Dec 1, 1987·The Journal of Pediatrics·G FeutrenJ F Bach
Jan 1, 1986·European Journal of Clinical Pharmacology·J GrevelK Kutz
Feb 1, 1985·Transplantation·K SugimotoR J Corry
Jan 1, 1985·Therapeutic Drug Monitoring·R P AgarwalG A Threatte
Aug 1, 1985·Transplantation·R J PtachcinskiT R Hakala
Nov 1, 1985·Seminars in Liver Disease·R VenkataramananR J Ptachcinski
May 1, 1986·Annals of Internal Medicine·R MartellJ Dupre
Mar 1, 1986·British Journal of Clinical Pharmacology·A JohnstonD W Holt
Nov 28, 1985·The New England Journal of Medicine·R J PtachcinskiJ T Rosenthal
Oct 9, 1982·Lancet·S DurrantE C Gordon-Smith
Oct 16, 1982·Lancet·R M FergusonJ S Najarian
Nov 27, 1982·Lancet·M A BoogaertsR L Verwilghen
Nov 27, 1982·Lancet·H Dieperink, J Møller
Nov 1, 1982·The Journal of Pharmacy and Pharmacology·M Lemaire, J P Tillement
Sep 15, 1984·Lancet·N J DanielsR K Schachter
Feb 1, 1984·Transplantation·D J WhiteG Cauwenbergh
Oct 1, 1984·Journal of Clinical Pathology·K AtkinsonJ Biggs
Dec 1, 1984·British Journal of Clinical Pharmacology·D J FreemanS G Carruthers
Nov 1, 1983·Clinical Pharmacology and Therapeutics·F FollathA Wood
Apr 1, 1984·Biochemical Pharmacology·P H WhitingJ G Simpson
Jan 1, 1981·International Journal of Immunopharmacology·D A IsenbergJ Mowbray
Jan 1, 1981·Journal of Immunoassay·P DonatschR Voges
Jun 13, 1980·Journal of Chromatography·W NiederbergerT Beveridge


Jul 1, 1996·Journal of Clinical Pharmacology·M MochonB A Kaiser
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·A KellesB Van Damme
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M BerkovitchG Koren
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L C Hymes
Jan 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Birgitta KranzPeter F Hoyer
Jun 1, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Outi JauholaMatti Nuutinen
Mar 26, 2004·Transplantation Proceedings·D Abendroth
Mar 26, 2004·Transplantation Proceedings·Lars PapeGisela Offner
Mar 26, 2004·Transplantation Proceedings·M H KapturczakB Kaplan
Jan 1, 1994·Acta Paediatrica·P CochatD Floret
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J F CrockerD H McLellan
Jan 1, 1992·European Journal of Pediatrics·Gisela OffnerJ Brodehl
Nov 29, 2011·Néphrologie & thérapeutique·Patrick Niaudet
Mar 31, 2004·Pediatric Transplantation·Peter F Hoyer
Aug 19, 2003·Pharmacotherapy·Renee F RobinsonDonald L Batisky
Sep 12, 2000·Bone Marrow Transplantation·C PetersInternational BFM Study Group--Subcommittee Bone Marrow Transplantation (IBFM-SG)
Mar 17, 2006·Journal of the American Society of Nephrology : JASN·Peter F Hoyer, Johannes Brodeh
Sep 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rita R AllowaySteven K Takemoto
Sep 26, 2001·Current Opinion in Critical Care·B D Kahan, S M Koch
Feb 11, 1998·Transplantation·G NybergI Kjellmer
May 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Udo VesterPeter F Hoyer
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BökenkampJ Brodehl

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