Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle

Organic Letters
Eric Assen B KantchevJackie Y Ying

Abstract

A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck-Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.

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Citations

Aug 27, 2014·Chemical Communications : Chem Comm·Frédéric IzquierdoSteven P Nolan
Feb 26, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Ramesh MamidalaKrishnan Venkatasubbaiah
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Feb 10, 2011·Chemistry : a European Journal·Aditya L GottumukkalaAdriaan J Minnaard
Apr 28, 2009·The Journal of Organic Chemistry·Takashi HoshiHisahiro Hagiwara

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