PMID: 12772518May 30, 2003Paper

Practical issues in adjuvant therapy for rectal cancer

Annals of the Academy of Medicine, Singapore
J J TjandraM W Chao

Abstract

While the standard adjuvant therapy for rectal cancer includes radiation therapy (RT) and chemotherapy (CT), the optimal treatment combination and sequencing have yet to be determined. In recent years, a large number of clinical trials have been reported in this rapidly evolving field. A review of pivotal trials in rectal cancer was undertaken with a focus on the important recent literature that has determined the current approach to adjuvant treatment. Multiple well-conducted, randomised studies have demonstrated that, for patients with stage II and III rectal cancer, the combination of adjuvant CT and RT reduces the risk of local recurrence (LR) and distant recurrence, improves overall survival and should form part of the standard treatment. Due to the reduced risk of LR, the absolute benefit from adjuvant RT is less if optimal oncologic surgery has been performed. Theoretical advantages and preliminary clinical results suggest that delivering part of the adjuvant therapy preoperatively will produce superior results. Ongoing randomised trials will define the relative merits of long-course RT (with CT) and short-course RT alone as preoperative therapy. Preoperative combined modality therapy might increase the rate of sphincter...Continue Reading

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