Practical methods for improving flow properties of active pharmaceutical ingredients

Drug Development and Industrial Pharmacy
Kalyana C PingaliFernando J Muzzio

Abstract

The essential aim of this article is to develop effective methods for improving the flow properties of active pharmaceutical ingredients (APIs) without requiring particle size or shape modification. The 'formulation' approach used here focuses on enhancing flow properties of three chemically different drug powders (micronized acetaminophen, levalbuterol tartrate, and didesmethylsibutramine tartrate) by using small amounts of lubricants, glidants, and other additives, both individually and in combination. Additives are intimately mixed using a laboratory-scale V-blender with an intensifier bar. Flow index, dilation, and electrical impedance were measured for a total of 24 blends. The flow behavior of all three APIs improved with the addition of these additives. Relative effectiveness of different additive combinations displayed remarkable consistency for all three APIs. Simultaneous presence of SiO2, MgSt, and talc led to substantial decreases in cohesiveness, causing major improvements in flowability of powder. All three properties showed a very tight correlation. Drug powders with improved flow were found to exhibit low dilation and low impedance values. A common linear correlation between flow index and impedance and also bet...Continue Reading

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Citations

Jul 31, 2013·AAPS PharmSciTech·Garett Morin, Lauren Briens
Jul 12, 2012·Drug Development and Industrial Pharmacy·Takehiko HorioShuji Matsusaka
Mar 2, 2011·International Journal of Pharmaceutics·Kalyana PingaliFernando Muzzio
Feb 21, 2019·Drug Development and Industrial Pharmacy·Hitesh DalvadiSuryabali Yadav
Jun 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Edina SzabóZsombor K Nagy
Oct 1, 2021·Drug Development and Industrial Pharmacy·Rahul Sharma, Gautam Setia
Nov 12, 2021·Drug Development and Industrial Pharmacy·Paulo J SalústioPaulo J Costa

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