Practical p-value adjustment for optimally selected cutpoints

Statistics in Medicine
S G Hilsenbeck, G M Clark

Abstract

This paper concerns a series of simulations undertaken to examine the effects of two data features--number of cutpoints and true marker prognostic effect size--on three methods of p-value adjustment (asymptotic, P(acor); improved Bonferroni, P(bon); and empirical permutation, P(emp)). H(o) rejection rates for P(emp) and P(bon) are almost indistinguishable from those for an independent validation sample (P(vld)), while those of P(acor) are somewhat conservative, especially when the number of cutpoints is small. Analysis of a new breast cancer prognostic marker, heat shock protein 70, illustrates the methods. These results underscore many of the problems associated with data-derived cutpoints in general, and the need for p-value adjustment.

Citations

Dec 16, 2006·BMC Medical Informatics and Decision Making·Harukazu Tsuruta, Leon Bax
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lawrence P LeichmanCharles D Blanke
Oct 22, 2004·The New England Journal of Medicine·Lori E Dodd, Richard Simon
May 26, 2004·Statistics in Medicine·Norbert HolländerMartin Schumacher
Oct 12, 2005·Statistics in Medicine·Patrick RoystonWilli Sauerbrei
Feb 19, 2003·Statistics in Medicine·Madhu MazumdarJennifer Bacik
Mar 1, 2000·Statistics in Medicine·F Dannegger
Dec 31, 1997·Journal of the National Cancer Institute·G M ClarkN W Kim
Jan 31, 2002·Anesthesiology·David AmarAlan H Kadish
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Syed K MohsinD Craig Allred
Feb 25, 2005·Anesthesia and Analgesia·Thomas ComfereDavid O Warner
Jan 24, 2008·Journal of Evaluation in Clinical Practice·John L MoranUNKNOWN Australian and New Zealand Intensive Care Society Clinical Trials Group
Dec 19, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Peter BankheadPeter W Hamilton
Jun 19, 2012·Breast Cancer Research and Treatment·Jasmina Z CerneSean E McGuire
Apr 25, 2013·Journal of Biopharmaceutical Statistics·Min SuZheng Su
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Mar 1, 2000·Statistics in Medicine·A KlingerK Ulm
Aug 27, 2003·Statistical Methods in Medical Research·Georgia Salanti, Ulm Kurt
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·S P StoeszM N Gould
Jan 4, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Prateek V JainPattatheyil Arun
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rudolf NapieralskiGisela Keller
Jun 26, 2001·Kidney International·N ChaturvediJ H Fuller
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·T F PajakM E Hammond
May 18, 2021·Circulation. Arrhythmia and Electrophysiology·Yoshihide TakahashiTetsuo Sasano

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