Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion.

International Journal of Legal Medicine
Gudrun HøisethJørg Mørland

Abstract

In postmortem toxicology, it could be difficult to determine whether a positive blood ethanol concentration reflects antemortem ingestion or postmortem synthesis of alcohol. Measurement of the nonoxidative ethanol metabolite ethyl glucuronide (EtG) has been suggested as a marker of antemortem ingestion of alcohol, but EtG might degrade postmortem which could make interpretation difficult. So far, the published articles concern EtG only. Another nonoxidative metabolite, ethyl sulfate (EtS), which is more stable, has therefore been included in this study. We present a material of 36 deaths where postmortem formation of ethanol was suspected and where both EtG and EtS were measured in blood and urine to assist the interpretation. In 19 cases, EtG and EtS were positive in the body fluids analyzed. The median concentration of EtG and EtS in blood was 0.4 (range 0.1-23.2) and 0.9 mg/L (range 0.04-7.9), respectively. The median concentration of EtG and EtS in urine was 35.9 (range 1.0-182) and 8.5 mg/L (range 0.3-99), respectively. In another 16 cases, there was no trace of EtG or EtS in the specimens analyzed. In one case, there was inconsistency between the results of EtG and EtS; they were both positive in urine, while only EtS was...Continue Reading

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Citations

Nov 10, 2010·International Journal of Legal Medicine·Nathalie CartiserJérôme Guitton
Jan 11, 2011·Journal of Addictive Diseases·R Gregory LandeAudrey S Chang
Jun 18, 2014·International Journal of Legal Medicine·Hege KrabsethGudrun Høiseth
Sep 15, 2010·International Journal of Legal Medicine·Frank MusshoffBurkhard Madea
Oct 11, 2011·International Journal of Legal Medicine·Cristian Palmiere, Patrice Mangin
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Mar 4, 2011·Forensic Science International : Synergy·Annette ThieraufWolfgang Weinmann
May 1, 2016·Journal of Forensic and Legal Medicine·S L Belsey, R J Flanagan
Nov 1, 2016·Journal of Analytical Toxicology·Solfrid HegstadOlav Spigset
Sep 2, 2015·Journal of Analytical Toxicology·Kamisha L Johnson-Davis, Matthew H Slawson
Sep 18, 2020·International Journal of Legal Medicine·Zijie LinYulan Rao
Jun 7, 2019·Traffic Injury Prevention·Anja ValenHallvard Gjerde
Nov 19, 2020·Journal of Analytical Toxicology·Xiaomin ChenYan Jiang
Mar 22, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hao WangYulan Rao

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