Practical Use of Regularization in Individualizing a Mathematical Model of Cardiovascular Hemodynamics Using Scarce Data

Frontiers in Physiology
Ali TivayJin-Oh Hahn

Abstract

Individualizing physiological models to a patient can enable patient-specific monitoring and treatment in critical care environments. However, this task often presents a unique "practical identifiability" challenge due to the conflict between model complexity and data scarcity. Regularization provides an established framework to cope with this conflict by compensating for data scarcity with prior knowledge. However, regularization has not been widely pursued in individualizing physiological models to facilitate patient-specific critical care. Thus, the goal of this work is to garner potentially generalizable insight into the practical use of regularization in individualizing a complex physiological model using scarce data by investigating its effect in a clinically significant critical care case study of blood volume kinetics and cardiovascular hemodynamics in hemorrhage and circulatory resuscitation. We construct a population-average model as prior knowledge and individualize the physiological model via regularization to illustrate that regularization can be effective in individualizing a physiological model to learn salient individual-specific characteristics (resulting in the goodness of fit to individual-specific data) whil...Continue Reading

References

Feb 11, 2009·Journal of the Royal Society, Interface·Tina ToniMichael P H Stumpf
May 16, 2009·Journal of Diabetes Science and Technology·Boris P KovatchevClaudio Cobelli
Jun 26, 2009·Annals of Biomedical Engineering·Jan-Willem LankhaarNico Westerhof
Apr 7, 2010·Physical Review Letters·Mark K TranstrumJames P Sethna
Jun 10, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas M HemmerlingPierre A Mathieu
Jul 9, 2010·Anesthesiology·Robert G Hahn
Jul 21, 2010·Biomedical Engineering Online·José L OrtizPablo R Olmos
Mar 17, 2011·IET Systems Biology·A RaueJ Timmer
Jun 20, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Jin-Oh HahnJ Mark Anersmino
Aug 21, 2013·IEEE Transactions on Bio-medical Engineering·Ramin Bighamian Jin-Oh Hahn
Nov 2, 2013·Science·Benjamin B MachtaJames P Sethna
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Joseph RinehartMaxime Cannesson
May 1, 2015·Science Translational Medicine·David BrownYoram Vodovotz
Jul 15, 2015·The Journal of Chemical Physics·Mark K TranstrumJames P Sethna
Sep 20, 2016·Frontiers in Physiology·Ramin BighamianJin-Oh Hahn
Dec 7, 2016·PLoS Computational Biology·Andrew WhiteMark K Transtrum
Feb 6, 2017·Computer Methods and Programs in Biomedicine·Antoine PironetThomas Desaive
Jul 7, 2017·Critical Care Medicine·Gabriel HundeshagenMichael P Kinsky
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Henry H MattinglyBenjamin B Machta
Jun 12, 2018·Control Engineering Practice·Ramin BighamianJin-Oh Hahn
Jul 19, 2018·Mathematical Biosciences·Andrew D MarquisMette S Olufsen
Nov 20, 2018·IEEE Transactions on Bio-medical Engineering·Xin JinJin-Oh Hahn
Feb 5, 2019·IEEE Journal of Biomedical and Health Informatics·Liangliang ZhangSeungik Baek
Jul 13, 2019·Frontiers in Physiology·Pras PathmanathanRichard A Gray

❮ Previous
Next ❯

Citations

Nov 16, 2020·Burns : Journal of the International Society for Burn Injuries·Ghazal ArabidarrehdorJose Salinas
Sep 10, 2021·Mathematical Medicine and Biology : a Journal of the IMA·Laura D'OrsiAndrea De Gaetano

❮ Previous
Next ❯

Software Mentioned

MATLAB
MATLAB Toolbox
matplotlib
Simulink

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neural Networks : the Official Journal of the International Neural Network Society
Masashi Sugiyama, Hidemitsu Ogawa
Annals of Internal Medicine
P D Gerber
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Yuan Peng, Yulong Mo
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Alireza Mazloumi Gavgani, Yesim Serinagaoglu Dogrusoz
IEEE Transactions on Neural Networks and Learning Systems
Yi WangLap-Pui Chau
© 2022 Meta ULC. All rights reserved