Practical utility of amyloid and FDG-PET in an academic dementia center

Neurology
Pascual Sánchez-JuanGil D Rabinovici

Abstract

To evaluate the effect of amyloid imaging on clinical decision making. We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent amyloid (Pittsburgh compound B [PiB]) PET as part of observational research studies and were evaluated clinically before and after the scan. One hundred thirty-four concurrently underwent fluorodeoxyglucose (FDG)-PET. We assessed for changes between the pre- and post-PET clinical diagnosis (from Aβ to non-Aβ diagnosis or vice versa) and Alzheimer disease treatment plan. The association between PiB/FDG results and changes in management was evaluated using χ(2) and multivariate logistic regression. Postmortem diagnosis was available for 24 patients (17%). Concordance between scan results and baseline diagnosis was high (PiB 84%, FDG 82%). The primary diagnosis changed after PET in 13/140 patients (9%) overall but in 5/13 (38%) patients considered pre-PET diagnostic dilemmas. When examined independently, discordant PiB and discordant FDG were both associated with diagnostic change (unadjusted p < 0.0001). However, when examined together in a multivariate logistic regression,...Continue Reading

Citations

Sep 6, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Daniela PeraniGiuseppe Magnani
Nov 7, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mehran M Sadeghi
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·David BergeronRobert Laforce
Dec 15, 2015·Revista española de medicina nuclear e imagen molecular·I BanzoJ M Carril
Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
Jun 24, 2015·Revista española de medicina nuclear e imagen molecular·Javier ArbizuJosé Luis Molinuevo
Feb 11, 2015·Human Pathology·Shino MagakiHarry V Vinters
Nov 12, 2014·Annual Review of Pathology·Harry V Vinters
Dec 23, 2014·Neurodegenerative Disease Management·Bradford C Dickerson
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·Mohamed Reda BensaïdaneRobert Laforce
Feb 27, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Robert LaforceS Gauthier
Jul 1, 2016·Brain : a Journal of Neurology·Gaël ChételatGil D Rabinovici
Aug 10, 2016·AJR. American Journal of Roentgenology·Erica L Martin-MacintoshPatrick J Peller
Aug 10, 2016·AJR. American Journal of Roentgenology·Erica L Martin-MacintoshPatrick J Peller
Oct 22, 2016·Journal of Alzheimer's Disease : JAD·Philip S J WestonJonathan M Schott
Aug 9, 2017·Dementia and Geriatric Cognitive Disorders·Michael J PontecorvoMark A Mintun
Oct 12, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Christopher James CarswellRichard J Perry
Sep 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Matthias BrendelAxel Rominger
Jul 22, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Robert LaforceRik Ossenkoppele
Oct 11, 2019·Clinical Drug Investigation·Angela AungstDerrick Robertson
Jun 18, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Hannah E BrunetMarwan Noel Sabbagh
Nov 7, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mathieu CeccaldiEric Guedj
Sep 22, 2020·PloS One·Alicia López-de-EguiletaAlfonso Casado
Sep 26, 2020·Practical Neurology·Magdalena A KolankoParesh A Malhotra
Feb 18, 2017·Current Neurology and Neuroscience Reports·Joseph C Masdeu
Feb 9, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Joshua D GrillLiana G Apostolova
Aug 11, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Sabine HellwigPhilipp T Meyer
Jun 30, 2018·Yeungnam University Journal of Medicine·Kyung Ah Chun
Oct 3, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Miriam T AshfordRachel L Nosheny
May 6, 2017·Alzheimer's Research & Therapy·Joshua D GrillJason Karlawish
Jan 18, 2017·Alzheimer's Research & Therapy·Marissa D ZwanPhilip Scheltens
May 2, 2018·Journal of Alzheimer's Disease : JAD·Carmen LagePascual Sánchez-Juan
Aug 1, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Giulia PeriniAgneta Nordberg
Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Yat-Fung SheaRanjan Duara
Apr 9, 2019·Journal of Alzheimer's Disease : JAD·Wei-Wei LiYan-Jiang Wang
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·David BergeronRobert Laforce
Nov 16, 2017·Alzheimer Disease and Associated Disorders·Rafid MustafaLiana G Apostolova
Nov 26, 2019·Neurologic Clinics·Joseph C Masdeu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Researcher Network:CZI Neurodegeneration Challenge

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Manabu Tashiro
Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T
L Boucher, F Bénard
Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T
D Groshar, G M Segall
International Journal of Radiation Oncology, Biology, Physics
Lilie L LinPerry W Grigsby
© 2021 Meta ULC. All rights reserved