Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial

Resuscitation
Matthew B A HarmonTTM trial investigators

Abstract

Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36). Mechanical ventilation data were obtained at three time points: 1) before TTM; 2) at the end of TTM (before rewarming) and 3) after rewarming. Logistic regression was used to determine an association between mechanical ventilation variables and outcome. Repeated-measures mixed modelling was performed to determine the effect of TTM on ventilation settings. Mechanical ventilation data was available for 567 of the 950 TTM patients. Of these, 81% was male with a mean (SD) age of 64 (12) years. At the end of TTM median tidal volume was 7.7 ml/kg predicted body weight (PBW)(6.4-8.7) and 60% of patients were ventilated with a tidal volume ≤ 8 ml/kg PBW. Median ...Continue Reading

Citations

Aug 17, 2018·Critical Care : the Official Journal of the Critical Care Forum·Christopher NewellJasmeet Soar
Nov 10, 2018·Therapeutic Hypothermia and Temperature Management·Marko NocPhilip E Empey
Nov 16, 2018·Therapeutic Hypothermia and Temperature Management·Graham NicholGregory Kapinos
Apr 30, 2020·Current Opinion in Critical Care·Glenn M Eastwood, Alistair Nichol
May 28, 2020·Therapeutic Hypothermia and Temperature Management·June-Sung KimWon Young Kim
Dec 15, 2020·Current Opinion in Critical Care·Fabienne D SimonisMarcus J Schultz
Dec 19, 2020·Intensive Care Medicine Experimental·Chiara RobbaPaolo Pelosi

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