Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.

Ocular Oncology and Pathology
Christina BinderAlison H Skalet

Abstract

Treatment planning for I-125 plaque therapy for uveal melanoma has advanced significantly since the Collaborative Ocular Melanoma Study trial, with more widely available image-guided planning and improved dosimetry. We evaluated real-world practice patterns for I-125 plaque brachytherapy in the United States by studying practice patterns at centers that comprise the Ocular Oncology Study Consortium (OOSC). The OOSC database and responses to a treatment practice survey were evaluated. The database contains treatment information from 9 institutions. Patients included in the database were treated between 2010 and 2014. The survey was conducted in 2018 and current treatment planning methods and prescriptions were queried. Examination of the OOSC database revealed that average doses to critical structures were highly consistent, with the exception of one institution. Survey responses indicated that most centers followed published guidelines regarding dose and prescription point. Dose rate ranged from 51 to 118 cGy/h. As of 2018, most institutions use pre-loaded plaques and fundus photographs and/or computed tomography or magnetic resonance imaging in planning. While there were differences in dosimetric practices, overall agreement i...Continue Reading

References

Jul 27, 2001·Archives of Ophthalmology·M Diener-WestUNKNOWN Collaborative Ocular Melanoma Study Group
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Melvin A Astrahan
Jan 16, 2008·Archives of Ophthalmology·Arghavan AlmonyJ William Harbour
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May 1, 2012·American Journal of Ophthalmology·Michael C ChappellTheodore L Phillips
Sep 21, 2013·Investigative Ophthalmology & Visual Science·Mahdi BayatMostafa Fatemi
Jan 1, 2014·Brachytherapy·UNKNOWN American Brachytherapy Society - Ophthalmic Oncology Task Force. Electronic address: paulfinger@eyecancer.com, UNKNOWN ABS – OOTF Committee
Jan 11, 2014·Investigative Ophthalmology & Visual Science·Zélia M Corrêa, James J Augsburger
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May 28, 2017·Ophthalmology·Prithvi MruthyunjayaUNKNOWN Ocular Oncology Study Consortium
Jan 24, 2020·Retina·Duncan E BerryUNKNOWN Ocular Oncology Study Consortium

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