Practice Trends of Fibrinogen Monitoring in Thrombolysis

Journal of Clinical Medicine
Claire KaufmanKeith Quencer

Abstract

There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society of Interventional Radiology, consisting of 23 questions related to practitioner demographics, thrombolysis protocol, and fibrinogen monitoring. There were 455 physician responses; 82% of respondents monitored fibrinogen levels during thrombolysis, of which 97% decreased or stopped tissue plasminogen activator based on the level. Self-reported estimates of significant bleeding events during thrombolysis were 1.86% in those who monitored fibrinogen and 1.93% in those who did not. Only 34% of all respondents report, in their clinical experience, having found low fibrinogen level to be correlated with bleeding events. There was no significant difference in self-reported major bleeding rates between practitioners who monitor and those who do not monitor fibrinogen. This high variability of clinical use of fibrinogen monitoring during catheter-directed thrombolysis is secondary to the paucity of scientific studies demonst...Continue Reading

References

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Dec 7, 2017·The New England Journal of Medicine·Suresh VedanthamUNKNOWN ATTRACT Trial Investigators

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Citations

Jun 17, 2020·Research and Practice in Thrombosis and Haemostasis·Christopher D BarrettMichael B Yaffe
May 21, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Lauren K Stewart, Jeffrey A Kline

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