Pragmatic comparison of beta2-agonist side effects within the Worldwide Atosiban versus Beta Agonists study

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jerry ChanNicholas M Fisk

Abstract

While beta2-agonists for the acute treatment of preterm labour unequivocally reduce the odds of delivery within 48 h and 7 days, they have been associated with substantial maternal and fetal side effects. We aimed to compare side effect profiles of beta2-agonist tocolytics. Pragmatic comparison of ritodrine, salbutamol and terbutaline from re-analysis of data obtained within three comparator arms of three simultaneous comparable randomised controlled trials of beta2-agonists against atosiban in 742 women in preterm labour. The prevalence of categoric side effects between treatment groups was analysed using a chi2 test. The differences in continuous variables between treatment groups were analysed in analyses of covariance. The prevalence of categoric side effects was similar with the three drugs, with the exception of the subjective symptom of palpitations (ritodrine 24.0%, terbutaline 9.3% and salbutamol 12.3%, P=0.003). There were also some differences in maternal diastolic blood pressure (P<0.001) and serum glucose levels (P<0.001), although these were small (<3 mmHg and < or =2.8 mmol/L, respectively) and clinically unimportant. Side effects were common with all three drugs. Thus, choosing one beta2-agonist over the other t...Continue Reading

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Citations

Jan 6, 2010·Journal of Perinatal Medicine·Jorge BurgosLuis Fernández-Llebrez
Apr 16, 2011·European Journal of Clinical Pharmacology·Isabelle G FabryLuc M Van Bortel
Nov 17, 2010·European Journal of Clinical Pharmacology·Isabelle FabryLuc Van Bortel
Apr 1, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Amir WeissmanArie Drugan
May 31, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jaro WexGian Carlo Di Renzo
Jul 13, 2012·Journal of Korean Medical Science·Young-Sun ParkMoon-Il Park
Sep 20, 2016·The Journal of Obstetrics and Gynaecology Research·Masamitsu NakamuraAkihiko Sekizawa

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