Pramlintide reduces the risks associated with glucose variability in type 1 diabetes.

Diabetes Technology & Therapeutics
Boris P KovatchevAnthony L McCall

Abstract

This study was designed to determine whether pramlintide added to insulin therapy reduced the risks associated with extreme blood glucose (BG) fluctuations in patients with type 1 diabetes. Self-monitored BG (SMBG) records were retrospectively analyzed from a randomized, double-blind, placebo-controlled study of the effects of pramlintide on intensively treated patients with type 1 diabetes. Two groups--pramlintide (n=119), 30/60 microg administered subcutaneously at each meal, or placebo (n=129)--were matched by age, gender, and baseline hemoglobin A1C. Using SMBG, daily BG profiles, BG rate of change, and low and high BG indices (LBGI and HBGI, respectively) measuring the risk for hypoglycemia and hyperglycemia were calculated. Compared with placebo, pramlintide significantly attenuated the pre- to postprandial BG rate of change (F=83.8, P<0.0001). Consequently, in pramlintide-treated patients, the average post-meal BG (8.4 vs. 9.7 mmol/L [151.2 vs. 174.6 mg/dL]) and postprandial HBGI were significantly lower than placebo (both P<0.0001). Substantial daily BG variation was observed in placebo-treated patients, with most significant hyperglycemia occurring after breakfast and during the night; post-meal BG did not vary signifi...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Mar 1, 1996·Diabetes Care·F E Van der DoesR J Heine
Jun 6, 1998·Diabetes Care·J J de SonnavilleR J Heine
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M FinemanO G Kolterman
May 27, 2003·Diabetes Care·Philip E CryerHarry Shamoon
Jun 11, 2003·Archives of Internal Medicine·John E Gerich
Sep 30, 2003·Diabetes Care·Rachel DerrChristopher D Saudek
Jun 16, 2004·Circulation·Katherine EspositoUNKNOWN Campanian Postprandial Hyperglycemia Study Group
Apr 28, 2005·Diabetes Care·UNKNOWN Workgroup on Hypoglycemia, American Diabetes Association
May 4, 2005·Journal of Diabetes and Its Complications·Irl B Hirsch, Michael Brownlee
Oct 27, 2006·Diabetes Care·Boris P KovatchevWilliam Clarke
Nov 2, 2006·Current Diabetes Reports·Laura L Want, Robert E Ratner

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Citations

Nov 10, 2010·Annals of Family Medicine·Nancy J LeeSujata Thakurta
Mar 10, 2009·Diabetes/metabolism Research and Reviews
Jul 30, 2009·Diabetes Care·Stephanie A Amiel
Jan 31, 2018·Journal of Molecular Endocrinology·Heather C Denroche, C Bruce Verchere
Mar 9, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·S A BrownB P Kovatchev
May 22, 2016·Diabetes Care·Boris Kovatchev, Claudio Cobelli
Nov 1, 2012·Expert Review of Endocrinology & Metabolism·Harold E Lebovitz

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