PMID: 2105373Feb 1, 1990Paper

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B-containing lipoproteins

Journal of Internal Medicine
G L VegaS M Grundy

Abstract

This study examined the actions of pravastatin on the metabolism of apolipoprotein B (apo B) in very low-, intermediate-, and low-density lipoproteins (VLDL, IDL, and LDL) in 10 patients with primary moderate hypercholesterolaemia. 131I-VLDL apo B was used as a tracer, and appearance of label was followed into IDL apo B and LDL apo B. Compared to placebo, pravastatin therapy reduced levels of cholesterol in total plasma. LDL, VLDL, and IDL cholesterol by 25%, 29%, 31%, and 47%, respectively. Pravastatin treatment also significantly decreased concentrations of apo B in LDL, IDL, and VLDL. The drug significantly reduced the mean production rate for VLDL apo B by 40%, and decreased production rates for LDL apo B in eight of 10 patients. In contrast, fractional catabolic rates (FCRs) were not altered significantly in any of the three lipoprotein fractions on pravastatin therapy. Further, pravastatin produced no consistent changes in LDL particle size, composition, or LDL subclass pattern. Thus pravastatin seemingly reduced input rates for all apo B-containing lipoproteins. Consistent with previous studies, this response was most likely the result of enhanced removal of nascent lipoproteins by increased activity of LDL receptors, al...Continue Reading

References

Mar 1, 1979·Metabolism: Clinical and Experimental·J L WitztumM A Dillingham
Jan 1, 1979·Annual Review of Genetics·J L Goldstein, M S Brown
Jun 1, 1988·Kidney International·G L Vega, S M Grundy
Jul 7, 1988·The New England Journal of Medicine·S M Grundy
Jan 14, 1988·The New England Journal of Medicine·A Garg, S M Grundy
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T MaM S Brown
Apr 15, 1986·The American Journal of Cardiology·J M HoegD L Sprecher
Feb 1, 1986·Metabolism: Clinical and Experimental·C A EastD W Bilheimer
Jul 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G L Vega, S M Grundy
Aug 1, 1985·The Journal of Clinical Investigation·G EgusaB V Howard
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P T KovanenM S Brown
Sep 1, 1983·The Journal of Clinical Investigation·M S Brown, J L Goldstein
Nov 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A H KissebahD J Evans
Dec 1, 1984·The Journal of Clinical Investigation·D R Illingworth, G J Sexton
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D W BilheimerJ L Goldstein
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A W AlbertsJ Springer
Mar 1, 1980·Atherosclerosis·A YamamotoA Endo
Jul 1, 1957·Physics in Medicine and Biology·C M MATTHEWS
Jul 5, 1958·Nature·A S McFARLANE
Feb 17, 1950·Science·J W GOFMAN, F LINDGREN

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Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·H Vanhanen, T A Miettinen
Jun 13, 1998·European Journal of Drug Metabolism and Pharmacokinetics·S SigurbjörnssonG Sigurdsson
Jun 16, 2006·Cardiovascular Drugs and Therapy·Manfredi Rizzo, Kaspar Berneis
Apr 15, 1991·Biochimica Et Biophysica Acta·C M Arbeeny, K E Bergquist
Jul 11, 2002·The American Journal of Cardiology·Frank M SacksLemuel A Moye
Jul 23, 1998·The Surgical Clinics of North America·A D Marks
Oct 12, 2000·Journal of the American College of Cardiology·J S ForresterS Kaul
May 20, 2003·Seminars in Dialysis·Stephen L Seliger, Catherine O Stehman-Breen
Jul 1, 1992·Postgraduate Medical Journal·J QuineyB Lewis
Feb 23, 2000·The Journal of Clinical Investigation·J TwiskA D Attie
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Weiqing TangLiqing Yu
Apr 5, 2003·The Journal of Laboratory and Clinical Medicine·Anuradha S PappuD Roger Illingworth
Aug 10, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Heiner K BertholdIoanna Gouni-Berthold
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G L VegaS M Grundy
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M CuchelA H Lichtenstein
Sep 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M W HuffP J Gillies
May 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A D Sniderman, K Cianflone
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G FranceschiniC R Sirtori
Feb 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A GawJ Shepherd
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J R BurnettM W Huff
Apr 29, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·W H SutherlandH L Walker
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D T SteinI Jialal

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