Praziquantel in the treatment of hepatosplenic schistosomiasis: biochemical disease markers indicate deceleration of fibrogenesis and diminution of portal flow obstruction

Transactions of the Royal Society of Tropical Medicine and Hygiene
K ZwingenbergerH Feldmeier

Abstract

Serological indicators for disease activity and portal vein obstruction and/or deviation were assessed in 23 patients with hepatosplenic schistosomiasis before, and up to 18 months after, praziquantel treatment, as well as in 25 matched local controls. Cessation of egg-induced immunopathology was reflected by the return to normal of serum procollagen-III-propeptide and neopterin concentrations. Reversibility of portal vein pathology was indicated by normal clearance of cholylglycine in cases without signs of decompensating portal hypertension. In most patients with a history of ascites and/or haemorrhage, serum cholylglycine concentration remained pathological. The results provide evidence that the fibrogenic process ceases after specific chemotherapy, and that portal vein pathology regresses in a substantial proportion of hepatosplenic schistosomiasis cases.

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Citations

Jan 27, 2016·International Journal for Parasitology·Candy ChuahGeoffrey N Gobert
May 28, 2013·The Korean Journal of Parasitology·Sayed Hassan Seif El-DinNaglaa Mohamed El-Lakkany
Nov 30, 2011·Memórias do Instituto Oswaldo Cruz·Ana Lúcia Coutinho DominguesEdmundo Pessoa de Almeida Lopes
Jan 31, 2006·Arquivos De Gastroenterologia·Rozangela Maria de Almeida Fernandes WyszomirskaElza Cotrim Soares
Nov 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·C B CançadoM F Lima e Costa
Dec 1, 1993·Annals of Tropical Medicine and Parasitology·J NdambaK C Kaondera
Jan 1, 2013·Journal of Biomarkers·Michael Eisenhut
Oct 1, 1990·Annals of Tropical Medicine and Parasitology·K ZwingenbergerH Feldmeier
Dec 29, 2020·Drugs -- Real World Outcomes·Christopher Kenneth OpioPonsiano Ocama
Feb 5, 2005·Gastroenterología y hepatología·L C Da SilvaF J Carrilho

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