Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum

The American Journal of Tropical Medicine and Hygiene
Jeba Jesudoss ChelladuraiMatthew T Brewer

Abstract

Dipylidium caninum is a cosmopolitan cestode infecting dogs, cats, and humans. Praziquantel is a highly effective cestocidal drug and resistance in adult cestodes has not been reported. From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of D. caninum were clinically resistant to praziquantel and could not be resolved despite increasing the dose, frequency, and duration of treatment. Resistant isolates were identified and characterized by sequencing the 28S, 12S, and voltage-gated calcium channel beta subunit genes. Cases were only resolved following treatment with nitroscanate or a compounded pyrantel/praziquantel/oxantel product. Clinicians should be aware of this alarming development as treatment options for cestodes are limited in both human and veterinary medicine.

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Citations

Mar 15, 2019·Journal of the American Animal Hospital Association·Lindie B HessAntoinette Marsh
Feb 13, 2020·Parasitology·Sarah G H Sapp, Richard S Bradbury
May 31, 2020·Pathogens·Peerut ChienwichaiOnrapak Reamtong
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Jul 28, 2020·International Journal of Environmental Research and Public Health·Christina KantarakiaChrysa Voyiatzaki
Mar 25, 2020·Case Reports in Pediatrics·Hannah F ChongMichael L Chang
Mar 3, 2020·Current Opinion in Microbiology·Thomas J SharptonMichael Kent
Dec 12, 2020·International Journal for Parasitology. Drugs and Drug Resistance·Andrew C KotzeRoger K Prichard
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Jul 4, 2021·Acta Tropica·Nayana Ferreira de LimaMarina Clare Vinaud
Aug 4, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Georg von Samson-HimmelstjernaPeter Deplazes
Sep 3, 2021·PLoS Neglected Tropical Diseases·Peerut ChienwichaiOnrapak Reamtong
Dec 8, 2021·Scientific Reports·Cristiane S MoraisJosué de Moraes

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