PMID: 16501816Feb 28, 2006Paper

Prazosin blocks the glutamatergic effects of N-methyl-D-aspartic acid on lordosis behavior and luteinizing hormone secretion in the estrogen-primed female rat

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Adriana Inés LandaP A Gargiulo

Abstract

We have observed that intracerebroventricular (icv) injection of selective N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptor antagonists inhibits lordosis in ovariectomized (OVX), estrogen-primed rats receiving progesterone or luteinizing hormone-releasing hormone (LHRH). When NMDA was injected into OVX estrogen-primed rats, it induced a significant increase in lordosis. The interaction between LHRH and glutamate was previously explored by us and another groups. The noradrenergic systems have a functional role in the regulation of LHRH release. The purpose of the present study was to explore the interaction between glutamatergic and noradrenergic transmission. The action of prazosin, an alpha1- and alpha2b-noradrenergic antagonist, was studied here by injecting it icv (1.75 and 3.5 microg/6 microL) prior to NMDA administration (1 microg/2 microL) in OVX estrogen-primed Sprague-Dawley rats (240-270 g). Rats manually restrained were injected over a period of 2 min, and tested 1.5 h later. The enhancing effect induced by NMDA on the lordosis/mount ratio at high doses (67.06 +/- 3.28, N = 28) when compared to saline controls (6 and 2 microL, 16.59 +/- 3.20, N = 27) was abolished by prazosin administration (17.04 +/- 5.52,...Continue Reading

References

May 13, 1991·Neuroscience Letters·M M McCarthyH H Feder
Jan 1, 1995·Brain Research Bulletin·C E NavarroA O Donoso
Mar 1, 1995·Biochemical Pharmacology·M I ForrayK Gysling
Mar 1, 1994·Frontiers in Neuroendocrinology·D W Brann, V B Mahesh
Aug 1, 1996·European Journal of Pharmacology·J M MathéT H Svensson
Jul 7, 2000·Frontiers in Neuroendocrinology·J Bakker, M J Baum
Mar 17, 2001·Brain Research·S P Yang, J L Voogt
Sep 19, 2003·Brain Research Bulletin·Maristela Polachini Martins-AfférriJanete Aparecida Anselmo-Franci

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Citations

Jul 1, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Luis H Llano LópezPascual A Gargiulo

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