PMID: 9192872Jun 1, 1997Paper

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

Genes & Development
R K HurfordN Dyson

Abstract

The activity of the E2F transcription factor is controlled by physical association with the retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family members are thought to control different aspects of E2F activity, but it has been unclear what the respective functions of these proteins might be. To dissect the specific functions of pRB, p107, and p130 we have investigated how the expression of E2F-regulated genes is changed in cultures of primary cells lacking each of these family members. Whereas no changes were found in the expression of E2F-target genes in cells lacking either p107 or p130, deregulated expression of E2F targets was seen in cells lacking pRB and in cells lacking both p107 and p130. Surprisingly, the genes that were disregulated in these two settings were completely different. These findings show that pRB and p107/p130 indeed provide different functions in E2F regulation and identify target genes that are dependent on pRB family proteins for their normal expression.

References

Sep 24, 1992·Nature·T JacksR A Weinberg
Sep 24, 1992·Nature·A R ClarkeH te Riele
Apr 1, 1992·Current Opinion in Cell Biology·L F Johnson
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S W HiebertJ R Nevins
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SchulzeB Henglein
Jun 1, 1995·Molecular and Cellular Biology·E M HijmansR Bernards
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A AlmasanG M Wahl
Nov 15, 1994·Genes & Development·D GinsbergD M Livingston
Dec 1, 1993·Molecular and Cellular Biology·J A LeesK Helin
Dec 1, 1993·Genes & Development·D CobrinikR A Weinberg
Mar 26, 1993·Science·M Ohtsubo, J M Roberts
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhtaniJ R Nevins
Apr 1, 1996·Molecular and Cellular Biology·K MobergJ A Lees
Apr 1, 1996·Molecular and Cellular Biology·J KarlsederE Wintersberger
Jul 1, 1996·Molecular and Cellular Biology·J BotzP Jansen-Dürr
Jul 1, 1996·Molecular and Cellular Biology·X HuetJ M Blanchard
Jul 1, 1996·Genes & Development·M H LeeT Jacks
Jul 1, 1996·Genes & Development·D CobrinikT Jacks
Jun 1, 1996·Current Opinion in Cell Biology·I Sánchez, B D Dynlacht
Sep 1, 1996·Molecular and Cellular Biology·A SchulzeB Henglein
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·R E HerreraR A Weinberg
Dec 6, 1996·Science·C J Sherr

❮ Previous
Next ❯

Citations

May 4, 1999·International Journal of Cancer. Journal International Du Cancer·K FujimotoM Imamura
Nov 26, 1999·Journal of Cellular Biochemistry·F BonettoM G Paggi
May 29, 2000·Journal of Cellular Physiology·W D Cress, E Seto
May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Lavia, P Jansen-Dürr
Oct 12, 2001·Journal of Cellular Biochemistry·A CharlesZ X Xiao
Jul 13, 2002·Journal of Cellular Physiology·Tiziana ToniniPier Paolo Claudio
Jun 23, 1998·Trends in Genetics : TIG·G Mulligan, T Jacks
Mar 16, 2001·Biochimica Et Biophysica Acta·P D Adams
May 22, 2002·Biochimica Et Biophysica Acta·James DeGregori
Jan 13, 1998·Biochimica Et Biophysica Acta·R Bernards
Feb 5, 2000·Biochimica Et Biophysica Acta·H Müller, K Helin
Jan 16, 2002·Current Opinion in Genetics & Development·Alan Ho, Steven F Dowdy
Apr 8, 1998·Current Opinion in Genetics & Development·S Mittnacht
Apr 8, 1998·Current Opinion in Genetics & Development·K Weston
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F WuS Kuriyama
Aug 8, 1998·Trends in Cell Biology·C BouchardM Eilers
May 14, 1999·Trends in Biochemical Sciences·A Brehm, T Kouzarides
Apr 20, 2001·Critical Reviews in Oncology/hematology·H H Sedlacek
Oct 13, 2000·Molecular Cell·J L BruceN Dyson
Apr 5, 2000·Progress in Retinal and Eye Research·J D Zieske
May 3, 2003·Cancer Cell·Hugh Cam, Brian David Dynlacht
Aug 12, 2009·Cell Research·Francesco P FiorentinoAntonio Giordano
Apr 19, 2013·Nature Reviews. Molecular Cell Biology·Frederick A Dick, Seth M Rubin
Jul 24, 2013·Nature Reviews. Molecular Cell Biology·Cosetta BertoliRobertus A M de Bruin
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gregory DavidRonald A Depinho
Jul 31, 2009·The Journal of Biological Chemistry·Jun Hyun KimVimla Band
Aug 18, 2010·The Journal of Biological Chemistry·Ching-Chun LiaoJu-Ming Wang
Mar 13, 2009·The Journal of Biological Chemistry·Kristy R StengelErik S Knudsen
Nov 20, 2012·Journal of Biomolecular Structure & Dynamics·C RamakrishnanD Velmurugan
Mar 23, 2000·The Journal of Experimental Medicine·R HalabanJ Germino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.