PRDM9, a driver of the genetic map

PLoS Genetics
Corinne GreyBernard de Massy

Abstract

During meiosis, maternal and paternal chromosomes undergo exchanges by homologous recombination. This is essential for fertility and contributes to genome evolution. In many eukaryotes, sites of meiotic recombination, also called hotspots, are regions of accessible chromatin, but in many vertebrates, their location follows a distinct pattern and is specified by PR domain-containing protein 9 (PRDM9). The specification of meiotic recombination hotspots is achieved by the different activities of PRDM9: DNA binding, histone methyltransferase, and interaction with other proteins. Remarkably, PRDM9 activity leads to the erosion of its own binding sites and the rapid evolution of its DNA-binding domain. PRDM9 may also contribute to reproductive isolation, as it is involved in hybrid sterility potentially due to a reduction of its activity in specific heterozygous contexts.

References

May 1, 1983·Cell·J W SzostakF W Stahl
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F MargolinF J Rauscher
Oct 1, 1996·Trends in Genetics : TIG·J Forejt
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BoultonR J Redfield
Feb 26, 2000·Annual Review of Genetics·D Zickler, N Kleckner
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·S A WolfeC O Pabo
Jun 29, 2002·Nature Genetics·Alec J Jeffreys, Rita Neumann
Jul 20, 2002·Trends in Genetics : TIG·Martin J Lercher, Laurence D Hurst
Feb 3, 2005·Genetics·Mario Pineda-Krch, Rosemary J Redfield
Jul 1, 2005·Human Molecular Genetics·Alec J Jeffreys, Rita Neumann
Aug 10, 2005·Genome Biology·Shane C DillonXiaodong Cheng
Apr 4, 2006·Cell Cycle·Katsuhiko Hayashi, Yasuhisa Matsui
Oct 13, 2006·Bioinformatics·Zoë Birtle, Chris P Ponting
Oct 19, 2006·PLoS Genetics·Chris C A SpencerGil McVean
Mar 14, 2007·PLoS Genetics·Graham Coop, Simon R Myers
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Frédéric Baudat, Bernard de Massy
Jul 12, 2008·PLoS Genetics·Kenneth PaigenPetko M Petkov
Dec 17, 2008·Science·Ondrej MiholaJiri Forejt
Jan 3, 2009·PLoS Genetics·Ryan O Emerson, James H Thomas
Feb 20, 2009·PLoS Biology·Corinne GreyBernard de Massy
Feb 20, 2009·PLoS Biology·Emil D ParvanovKenneth Paigen
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Laurent Duret, Nicolas Galtier
Dec 10, 2009·PLoS Genetics·Peter L OliverChris P Ponting
Dec 31, 2009·PloS One·James H ThomasJay Shendure
Jan 2, 2010·Science·Emil D ParvanovKenneth Paigen
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gil McVean
Mar 11, 2011·Trends in Genetics : TIG·Chris P Ponting
Jul 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ingrid L BergAlec J Jeffreys
Oct 19, 2011·Genome Research·Erik AxelssonKerstin Lindblad-Toh

❮ Previous
Next ❯

Citations

Jun 13, 2019·Genome Research·Ondrej MiholaZdenek Trachtulec
May 10, 2020·Nucleic Acids Research·April L MuellerMarcus B Noyes
Sep 17, 2020·ELife·Mathilde Biot, Bernard de Massy
May 19, 2019·Andrology·J Feichtinger, R J McFarlane
Jun 4, 2020·Scientific Reports·Melak WeldenegodguadJuha Kantanen
Mar 4, 2019·Chromosoma·Cori K Cahoon, Diana E Libuda
Mar 4, 2020·Genes & Development·Kris G AlavattamSatoshi H Namekawa
Feb 14, 2020·Nature Communications·Jacob PaianoAndré Nussenzweig
Feb 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Meixia ZhaoDamon Lisch
Feb 23, 2021·Biological Reviews of the Cambridge Philosophical Society·Roberta BergeroSimone Immler
Apr 21, 2019·Molecular Cell·Michiel BoekhoutScott Keeney
May 28, 2019·Trends in Genetics : TIG·Lauren J Tracey, Monica J Justice
Dec 11, 2019·Trends in Cell Biology·Mireille BétermierJean-Pierre de Villartay
May 5, 2021·Frontiers in Cell and Developmental Biology·Kai O SkaftnesmoAnna Wargelius
Aug 7, 2021·Cell·Jason A Halliwell, Eva R Hoffmann
May 20, 2021·Journal of Experimental Botany·Yazhong WangCharles J Underwood
Jul 10, 2021·Trends in Genetics : TIG·Jiri ForejtEmil Parvanov
Nov 23, 2021·Frontiers in Cell and Developmental Biology·Benjamin AllevaRafael Daniel Camerini-Otero
Jun 5, 2019·Current Biology : CB·Sarah E Zanders, Robert L Unckless

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP
ChIP-Seq
two hybrid

Software Mentioned

switchSENSE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.