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PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

Science

Jan 2, 2010

F BaudatB de Massy

Abstract

Meiotic recombination events cluster into narrow segments of the genome, defined as hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. First, two mouse strains that differ in hotspot usage are polymorphic for the zinc finger DNA binding array...read more

Mentioned in this Paper

Zinc Fingers
Genome
PRDM9 gene
Recombination, Genetic
Transcription Initiation
Meiotic Recombination
Histone-Lysine N-Methyltransferase
Genetic Hotspot
Protein Domain
DNA Binding
8
6
597
1
2
Paper Details
References
  • References27
  • Citations402
123
  • References27
  • Citations402
12345...

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PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

Science

Jan 2, 2010

F BaudatB de Massy

PMID: 20044539

DOI: 10.1126/science.1183439

Abstract

Meiotic recombination events cluster into narrow segments of the genome, defined as hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. First, two mouse strains that differ in hotspot usage are polymorphic for the zinc finger DNA binding array...read more

Mentioned in this Paper

Zinc Fingers
Genome
PRDM9 gene
Recombination, Genetic
Transcription Initiation
Meiotic Recombination
Histone-Lysine N-Methyltransferase
Genetic Hotspot
Protein Domain
DNA Binding
8
6
597
1
2

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Science eTOC

Science Magazine is a peer-reviewed academic journal of the American Association for the Advancement of Science. Find the latest research from Science here.

Related Papers

Science

Prdm9 controls activation of mammalian recombination hotspots

ScienceJanuary 2, 2010
Emil D ParvanovKenneth Paigen
Paper Details
References
  • References27
  • Citations402
123
  • References27
  • Citations402
12345...
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