Abstract
To investigate the role of PRDX2 in esophageal carcinoma (ESCA). The expression of PRDX2 was detected in ESCA tissues. And PRDX2 expression in two ESCA cell lines was knocked down. Cell proliferation, metastasis and invasion were detected in these cells. Here, we found that PRDX2 expression was significantly increased in ESCA tissues and was associated with a poor prognosis in ESCA patients. In addition, PRDX2 expression was significantly associated with pathological grading, infiltration degree and 5-year survival time in ESCA patients. Next, we knocked down PRDX2 expression by PRDX2-shRNA transfection in two ESCA cell lines, Eca-109 and TE-1. Proliferation analysis indicated that in vitro PRDX2 knockdown decreased growth and clone formation of ESCA cells. Scratch and transwell assays indicated that cell migration and invasion were significantly inhibited by PRDX2 knockdown. In addition, PRDX2 knockdown inhibited cell cycle of ESCA cells and down-regulated Cyclin D1-CDK4/6. Moreover, PRDX2 knockdown regulated proteins involved in mitochondrial-dependent apoptosis, including increased Bax and Caspase9/3 and decreased Bcl2. Mechanism investigation indicated that PRDX2 knockdown led to inactivation of Wnt/β-catenin and AKT pathwa...Continue Reading
References
Feb 22, 2002·The Journal of Pathology·Vuokko L KinnulaY Soini
Jun 17, 2006·Cancer Research·Junichi FurutaToshikazu Ushijima
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jianguo FangStuart A Lipton
May 14, 2008·Current Cancer Drug Targets·Amancio CarneroJuan F M Leal
Sep 23, 2010·Proteomics·Shu DiaoHsiang-fu Kung
Jan 25, 2011·Journal of Surgical Oncology·Tad KimSteven N Hochwald
Dec 31, 2011·Blood·Shuchi Agrawal-SinghCarsten Müller-Tidow
Mar 21, 2012·Oncogene·V StresingA Sierra
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Quan JiangTao Yuan
Oct 16, 2013·Cancer Letters·Weidong LuJinbao Guo
Nov 16, 2013·Molecular and Cellular Biochemistry·Weidong LuJinbao Guo
Nov 26, 2013·Cell Reports·Jonathon D BrownElizabeth A Veal
Nov 26, 2013·International Journal of Molecular Medicine·Diego GuidolinKjell Fuxe
Apr 15, 2014·Chemistry & Biology·Cedric I BouziguesAntigoni Alexandrou
Jun 6, 2014·Annals of Medicine·Miriam MartiniEmilio Hirsch
Jun 13, 2014·Molecular Medicine Reports·Jihong FengShouru Zhang
Oct 24, 2014·International Journal of Oncology·Andrej NikoshkovSonia Andersson
Dec 5, 2014·Medical Oncology·Shouru ZhangKunli Du
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 8, 2016·Oncology Letters·Silei ZhouYuanfang Ma
Nov 29, 2016·Oncotarget·Rong WangZhongxue Fu
Jan 27, 2017·Oncotarget·LingLong PengZhongXue Fu
Feb 12, 2017·Clinical Proteomics·Lie-Hao LinYu-Hui Peng
Mar 7, 2017·BioMed Research International·Georgia KontostathiKalliopi I Pappa
Sep 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rong HeNing Shen
Dec 28, 2017·PloS One·Iram FatimaGustavo A Miranda-Carboni
Feb 10, 2018·Experimental & Molecular Medicine·Soo Hyun HongSang Won Kang
Mar 31, 2018·Acta Oncologica·Francesco CavallinCarlo Castoro
Citations
Sep 11, 2020·BioMed Research International·Yun ChenDan Su
Apr 4, 2021·Antioxidants·Lucie Valek, Irmgard Tegeder
Aug 14, 2021·Molecular Cancer·Yu ZhangXu Zhang
Sep 8, 2021·Frontiers in Genetics·Xueting RenZhangjian Zhou