PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption

Oncotarget
Hyung-Mun YunJin Tae Hong

Abstract

Multiple sclerosis (MS) is a complex disease with an unknown etiology and has no effective medications despite extensive research. Antioxidants suppress oxidative damages which are implicated in the pathogenesis of MS. In this study, we showed that the expression of an antioxidant protein peroxiredoxin 6 (PRDX6) is markedly increased in spinal cord of mice with experimental autoimmune encephalomyelitis (EAE) compared to other PRDXs. PRDX6 transgenic (Tg) mice displayed a significant decrease in clinical severity and attenuated demyelination in EAE compared to wide type mice. The increased PRDX6 expression in astrocytes of EAE mice and MS patients reduced MMP9 expression, fibrinogen leakage, chemokines, and free radical stress, leading to reduction in blood-brain-barrier (BBB) disruption, peripheral immune cell infiltration, and neuroinflammation. Together, these findings suggest that PRDX6 expression may represent a therapeutic way to restrict inflammation in the central nervous system and potentiate oligodendrocyte survival, and suggest a new molecule for neuroprotective therapies in MS.

References

Jan 1, 1994·Developmental Neuroscience·C F BrosnanS C Lee
Nov 1, 1994·Journal of Neuropathology and Experimental Neurology·E E Kwon, J W Prineas
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jan 9, 2003·Trends in Biochemical Sciences·Zachary A WoodLeslie B Poole
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
May 18, 2005·Neuroscience Letters·Mei-Hua JinDong-Seok Lee
Feb 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyoung-Jin MinEun-hye Joe
Oct 4, 2006·Neuron·Stephen L Hauser, Jorge R Oksenberg
Jul 12, 2007·Multiple Sclerosis : Clinical and Laboratory Research·J E HolleyN J Gutowski
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Pedram GhafourifarWoineshet J Zenebe
Dec 17, 2008·Neuropathology and Applied Neurobiology·D MahadD Turnbull
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Jan 17, 2013·Glia·Celia F Brosnan, Cedric S Raine

❮ Previous
Next ❯

Citations

Jul 26, 2016·Frontiers in Cell and Developmental Biology·Klaudia LepkaOrhan Aktas
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Bożena Adamczyk, Monika Adamczyk-Sowa
Aug 12, 2018·Molecular Neurobiology·In Jun YeoJin Tae Hong
Feb 16, 2017·Journal of Crohn's & Colitis·Hassan MelhemIsabelle Frey-Wagner
May 3, 2018·Journal of Lipid Research·Aron B Fisher
Jan 28, 2016·Molecules and Cells·Bernard KnoopsOksana Kuznetsova
Nov 28, 2018·Antioxidants·José A Arevalo, José Pablo Vázquez-Medina
Nov 8, 2020·Molecular Neurobiology·Amita Daverey, Sandeep K Agrawal
Nov 29, 2020·Glia·Sofia Pereira das NevesFernanda Marques
Dec 4, 2020·Antioxidants·Monika Szeliga
Jan 4, 2020·Free Radical Biology & Medicine·Lisa MullenPietro Ghezzi
Apr 9, 2021·The American Journal of Chinese Medicine·Kyung-Ran ParkHyung-Mun Yun
May 1, 2016·Pharmacology & Therapeutics·Mi Hee ParkJin Tae Hong
Jun 3, 2021·International Journal of Molecular Sciences·Rina AharoniRuth Arnon

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
light microscopy
Profiler
Assay

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.