Pre- and perinatal risk factors for pyloric stenosis and their influence on the male predominance

American Journal of Epidemiology
Camilla KroghThea K Fischer

Abstract

Pyloric stenosis occurs with a nearly 5-fold male predominance. To what extent this is due to environmental factors is unknown. In a cohort of all children born in Denmark, 1977-2008, the authors examined the association between pre- and perinatal exposures and pyloric stenosis and investigated whether these factors modified the male predominance. Information on pre- and perinatal factors and pyloric stenosis was obtained from national registers. Poisson regression models were used to estimate rate ratios. Among 1,925,313 children, 3,174 had surgery for pyloric stenosis. The authors found pyloric stenosis to be significantly associated with male sex, age between 2 and 7 weeks, early study period, being first born, maternal smoking during pregnancy, preterm delivery, small weight for gestational age, cesarean section, and congenital malformations. Among cases, 2,595 were males and 579 were females. Lower male predominance was associated with age at diagnosis outside the peak ages, early study period, no maternal smoking during pregnancy, preterm delivery, and congenital malformations. The authors have previously found a strong familial aggregation of pyloric stenosis indicating a genetic influence. This study shows that environm...Continue Reading

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Citations

Aug 6, 2014·Journal of Pediatric Surgery·Anna SvenningssonAgneta Nordenskjöld
Mar 6, 2016·Journal of Pediatric Surgery·Carolyn WayneAhmed Nasr
May 25, 2015·European Journal of Pediatrics·Kaisa KivistöSatu Kivitie-Kallio
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Nov 4, 2020·La Pediatria medica e chirurgica : Medical and surgical pediatrics·Salvatore Fabio ChiarenzaMaria Mendoza-Sagaon

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