Pre- and Post-diagnosis Diabetes as a Risk Factor for All-Cause and Cancer-Specific Mortality in Breast, Prostate, and Colorectal Cancer Survivors: a Prospective Cohort Study.

Frontiers in Endocrinology
Huan TaoXiong Chen

Abstract

Objective: The relationship between diabetes and all- and cause-specific mortality in individuals with common cancers (breast, colorectal, and prostate) remains both under-researched and poorly understood. Methods: Cancer survivors (N = 37,993) from the National Health Interview Survey with linked data retrieved from the National Death Index served as our study participants. Cox proportional-hazards models were used to assess associations between pre- and post-diabetes and all-cause and cause-specific mortality. Results: Over a median follow-up period of 13 years, 2,350 all-cause, 698 cancer, and 506 CVD deaths occurred. Among all cancer survivors, patients with diabetes had greater risk of: all-cause mortality [hazard ratio (HR) 1.35, 95% CI = 1.27-1.43], cancer-specific mortality (HR: 1.14, 95% CI = 1.03-1.27), CVD mortality (HR: 1.36, 95% CI = 1.18-1.55), diabetes related mortality (HR: 17.18, 95% CI = 11.51-25.64), and kidney disease mortality (HR: 2.51, 95% CI = 1.65-3.82), compared with individuals without diabetes. The risk of all-cause mortality was also higher amongst those with diabetes and specific types of cancer: breast cancer (HR: 1.28, 95% CI = 1.12-1.48), prostate cancer (HR: 1.20, 95% CI = 1.03-1.39), and color...Continue Reading

References

Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Jun 3, 2004·Annals of Internal Medicine·Michael M EngelgauK M Venkat Narayan
Nov 3, 2005·Nature Clinical Practice. Oncology·Lisa C Richardson, Lori A Pollack
Nov 17, 2005·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Sep 28, 2006·Diabetes Care·Christopher J SchofieldUNKNOWN DARTS/MEMO Collaboration
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jocelyn S Kasper, Edward Giovannucci
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Lonneke V van de Poll-FranseHarm R Haak
Mar 1, 2007·The Journal of Biological Chemistry·Alisa S Morss, Elazer R Edelman
Apr 9, 2008·Acta Physiologica Hungarica·H NandeeshaL N Dorairajan
Oct 31, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael Pollak
Dec 18, 2008·JAMA : the Journal of the American Medical Association·Bethany B BaroneFrederick L Brancati
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomasz P SrokowskiSharon H Giordano
Jun 19, 2009·Cell Communication and Signaling : CCS·Katerina MardilovichLeslie M Shaw
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Feb 11, 2010·Prostate Cancer and Prostatic Diseases·C F SnyderF L Brancati
Apr 6, 2012·Diabetologia·J A JohnsonUNKNOWN Diabetes and Cancer Research Consortium
Apr 6, 2012·Diabetologia·A G RenehanUNKNOWN Diabetes and Cancer Research Consortium
Aug 11, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Patricia WongYu-Xiao Yang
Oct 11, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W LuoF Gao
Sep 13, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KiderlenG J Liefers
Feb 25, 2014·Cancer Causes & Control : CCC·Eric A MillerKenneth C Schoendorf
May 21, 2015·Journal of Diabetes·Brandy J Lipton, Sandra L Decker
Jul 15, 2015·British Journal of Cancer·J LuoK L Margolis
Feb 15, 2018·International Journal of Cancer. Journal International Du Cancer·Yvette AmshoffLoïc Le Marchand
Oct 28, 2018·Breast Cancer Research and Treatment·Gertraud MaskarinecLoïc Le Marchand

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Citations

Jul 28, 2020·Nanomaterials·Chunhua Yang, Didier Merlin
Jul 10, 2021·Journal of the National Cancer Institute·William M P KleinRobin C Vanderpool

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