PMID: 517271Jan 1, 1979Paper

Pre- and post-synaptic inhibition

Advances in Experimental Medicine and Biology
K Krnjević

Abstract

We now know a great deal about central inhibitory mechanisms: how they are organized in various neuronal circuits ("feed-forward" and "feed-back" inhibitions, inhibition of inhibitory cells giving "disinhibition" which releases neuronal activity in a finely graded and particularly safe manner); how they exercise a preponderant control over much of central neurl activity (9, 13, 14, 57); and of course, how inhibition operates at the cell membrane, by increasing Cl- permeability; this has a stabilizing action post-synaptically, but presynaptically, in afferent fibers, it depresses transmitter release from afferent terminals. In addition, there is some evidence that GABA transport may be electrogenic and therefore may significantly modulate membrane excitability, and that GABA may selectively depress Ca2+ influx in afferent terminals and thus inhibit transmitter release particularly effectively. However, it is by no means certain that we are fully aware of all the possible ways in which GABA affects neuronal excitability and synaptic transmission, and there may well be further exciting surprises in store.

Citations

Nov 1, 1987·The International Journal of Neuroscience·H HydénA Palm
Dec 1, 1985·Neurochemical Research·E L Wee, E F Zimmerman

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