Pre- and postjunctional beta-adrenoceptor mediated effects on transmitter release and effector response in the isolated rat portal vein

Acta Physiologica Scandinavica
C DahlöfB Ablad

Abstract

Pre- and postjunctional control mechanisms of the portal vein of spontaneously hypertensive rats (SHR) were characterized. Emphasis was placed on the influence of the presynaptic beta-adrenoceptor mediated mechanism for regulation of neuronal noradrenaline (NA) release (studied as tritium overflow) and its consequences for the contractile response under in vitro conditions. It was found that isoprenaline increased, whereas dl-propranolol decreased the release of neuronal NA during transmural nerve stimulation, while effector responses remained unaltered. d-Propranolol and the beta-1 selective adrenoceptor antagonist, metoprolol, did not affect these two variables. It is concluded that the presynaptic beta-adrenoceptors in the rat portal vein are mainly of the beta-2 type and mediate facilitation of neuronal transmitter release and that concomitant changes of the effector responses of this tissue are below the level of detection under the present experimental conditions.

References

Mar 1, 1976·Acta Physiologica Scandinavica·L Stjärne, J Brundin
Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Oct 1, 1977·Physiological Reviews·T C Westfall
Mar 1, 1976·International Journal of Dermatology·F S MarcusM R Powell
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger
Aug 1, 1970·The Journal of Pharmacy and Pharmacology·B AbladB Waldeck
Nov 1, 1970·The Journal of Pharmacy and Pharmacology·A M Barrett, B Nunn
Aug 1, 1971·Die Naturwissenschaften·K Starke

❮ Previous
Next ❯

Citations

Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·O A Nedergaard
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·C DahlöfT H Svensson
Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·A Franco-Cereceda, J M Lundberg
Dec 17, 1981·European Journal of Pharmacology·S Arbilla, S Z Langer
Jul 1, 1983·Journal of the Autonomic Nervous System·T J VerbeurenP M Vanhoutte
Mar 5, 2003·Brain, Behavior, and Immunity·Virginia M SandersAdam P Kohm
Jul 1, 1985·Acta Physiologica Scandinavica·A Franco-CerecedaC Dahlöf
Oct 1, 1986·Medicinal Research Reviews·H Majewski, M J Rand
Apr 1, 1986·Medicinal Research Reviews·Y Misu, T Kubo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.