PMID: 9163640May 1, 1997Paper

Pre- and postjunctional inhibitory effects of fenspiride on guinea-pig bronchi

The European Respiratory Journal
V GirardC Advenier

Abstract

Fenspiride is a drug with potential benefits in the treatment of obstructive airways disease. It has antibronchoconstriction and anti-inflammatory properties. The aim of this study was to investigate the effect of this drug on the contractions induced in the guinea-pig isolated main bronchus and perfused lung by electrical field stimulation (EFS) or exogenously added agents. Bronchi were stimulated transmurally in the presence of indomethacin 10(-6) M and propranolol 10(-6) M, and isometric tension was measured. In the perfused lung model calcitonin gene-related peptide (CGRP) release was determined in the perfusate fractions as a measure of neuropeptide production. Two successive contractile responses were observed: a rapid cholinergic contraction, followed by a long-lasting contraction due to local release of neuropeptides from C-fibre endings. Fenspiride (10(-6) to 10(-4) M) inhibited the nonadrenergic, noncholinergic (NANC) component of the contraction of the guinea-pig isolated main bronchus induced by EFS. Fenspiride significantly affected contractions induced by exogenously added substance P or [Nle10]-NKA(4-10) only at concentrations higher than 10(-3) M. In the guinea-pig perfused lung, fenspiride inhibited low pH- but...Continue Reading

Citations

Oct 17, 2013·Bulletin of Experimental Biology and Medicine·N A KuzubovaO N Titova
Oct 19, 2013·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Nataliya A KuzubovaOlga N Titova
Dec 11, 2002·British Journal of Haematology·Valérie CostesPierre Brousset
Jul 12, 2003·Leukemia & Lymphoma·Haytham KhouryStephen H Nantel
Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Falko Fend, Markus Kremer
Mar 18, 2000·Leukemia & Lymphoma·M ParrensJ P Merlio

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