Pre- and postnatal Lactobacillus reuteri treatment alters DNA methylation of infant T helper cells.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
A ForsbergM C Jenmalm

Abstract

Perinatal childhood exposures, including probiotic supplementation, may affect epigenetic modifications and impact on immune maturation and allergy development. The aim of this study was to assess the effects of pre- and postnatal Lactobacillus reuteri supplementation on DNA methylation in relation to immune maturation and allergy development. DNA methylation patterns were investigated for allergy-related T helper subsets using a locus-specific method and at a genome-wide scale using the Illumina 450K array. From a randomised, double-blind, placebo-controlled allergy prevention trial with pre- and postnatal probiotic supplementation, CD4+ T helper cells were obtained at birth (from cord blood), and 12 and 24 months of age (total (placebo/probiotics); locus-specific method: CB = 32 (17/15), 12 months = 24 (9/15), 24 months = 35 (15/20); Illumina: CB = 19 (10/9), 12 months = 10 (6/4), 24 months = 19(11/8)). Comparing probiotics to placebo, the greatest genome-wide differential DNA methylation was observed at birth, where the majority of sites were hypomethylated, indicating transcriptional accessibility in the probiotic group. Bioinformatic analyses, including network analyses, revealed a module containing 91 genes, enriched for ...Continue Reading

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Citations

Nov 22, 2020·Scientific Reports·Adrienne M AntonsonTamar L Gur
Feb 16, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Mar 7, 2021·Nutrients·Nathalie AcevedoBetty C A M van Esch
Jul 10, 2021·Pediatric Research·Jennifer Bermick, Matthew Schaller

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