Pre- and postoperative therapy with GnRH agonist for endometrial resection. A prospective, randomized study

Acta Obstetricia Et Gynecologica Scandinavica
S S SørensenL O Vejerslev

Abstract

To assess the value of endometrial preparation, with preoperative and pre- and postoperative GnRH agonist therapy in transcervical endometrial resection. Sixty women with menorrhagia were randomly divided between three groups: A: no preoperative preparation, B: goserelin 3.6 mg given as a subcutaneous implant 4-6 weeks preoperatively, and C: the same regimen as B, and repeated on the day of endometrial resection. At follow-up visits 1, 3, 6 and 12 months after operations the patients were interviewed for duration, amount and pains of menstrual periods. The duration of surgery for the pretreated group (32.8 +/- 5.1 min) and the group treated postoperatively (30.9 +/- 8.9 min) were significantly shorter than that in the control group (46.4 +/- 11.5 min) (p < 0.01). The weight of endomyometrial strips was about 3 times lower for group B and C as compared to group A (p < 0.01). Three months following the procedure twenty five percent of patients in group A were amenorrheic or showed scanty bleeding as compared to 58% and 85% in group B and C (p < 0.05 and p < 0.01), respectively. At 12 months follow-up these rates were 35%, 58% and 67% respectively (A versus B: NS, A versus C: p < 0.05) and 24%, 65% and 75% after excluding larger s...Continue Reading

References

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Citations

Dec 31, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T KucukozkanM Besli
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alka KriplaniDeep Takkar
Apr 1, 2014·Journal of Minimally Invasive Gynecology·Christian ChristoffersenSøren Stampe Sørensen
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Julie BrownRoger J Hart
Nov 16, 2013·The Cochrane Database of Systematic Reviews·Yu Hwee Tan, Anne Lethaby
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Martin C SowterAmita A Singla
Apr 3, 2015·The Journal of Obstetrics and Gynaecology Research·Motoki TakenakaKen-ichiro Morishige
Feb 26, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Semih Z UludagErcan M Aygen

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