PMID: 9431927Feb 12, 1998Paper

Pre-AIDS era isolates of Pneumocystis carinii f. sp. hominis: high genotype similarity with contemporary isolates

Journal of Clinical Microbiology
A G TsolakiA E Wakefield

Abstract

Isolates of Pneumocystis carinii f. sp. hominis were examined from six individuals who died of P. carinii pneumonia between 1968 and 1981 and who had underlying immunodeficiencies which were not due to human immunodeficiency virus infection. DNA sequence variation was analyzed in the genes encoding the mitochondrial large subunit rRNA (mt LSU rRNA), the internal transcribed spacer (ITS) regions of the nuclear rRNA, the arom locus, and the mitochondrial small subunit rRNA. No major variations were observed when these isolates were compared to isolates from HIV-infected individuals. A small number of minor differences were detected. A new position at which variation occurred in the mt LSU rRNA was observed in one sample. Three new ITS sequence types were identified. A total of nine different ITS sequence types were found in the six samples. Mixed infection with different ITS sequence types of P. carinii f. sp. hominis was observed in four of the six samples. The ITS locus was the most informative of the four loci for distinguishing among the isolates of P. carinii f. sp. hominis. The data suggest that isolates of P. carinii f. sp. hominis from before the AIDS pandemic are genetically very similar to those currently found in HIV-i...Continue Reading

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Citations

Mar 11, 2009·Memórias do Instituto Oswaldo Cruz·S DerouicheC Demanche
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne TotetGilles Nevez
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Robert F MillerAnn E Wakefield
Oct 27, 2004·Emerging Infectious Diseases·Charles Ben BeardBettina Lundgren
Dec 16, 2006·The Journal of Eukaryotic Microbiology·Anne TotetGilles Nevez
Aug 21, 2010·Future Microbiology·Olga Matos, Francisco Esteves
Feb 14, 2014·Journal of Clinical Microbiology·Christian M ParobekJonathan J Juliano
Mar 22, 2002·The Journal of Eukaryotic Microbiology·G NevezC Raccurt
Oct 13, 2006·Current Opinion in Infectious Diseases·R F Miller
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Oct 31, 2000·Applied and Environmental Microbiology·R J PalmerA E Wakefield
Jan 23, 2004·The Journal of Eukaryotic Microbiology·Robert F MillerAnn E Wakefield
Feb 9, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liang MaJoseph A Kovacs
Mar 25, 2017·Medical Mycology·Patrizia DanesiRichard Malik
Nov 5, 2020·Journal of Fungi·Lana PasicWieland Meyer
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May 4, 2004·Molecular Phylogenetics and Evolution·Jacques GuillotRené Chermette
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Jun 21, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cécile-Marie Aliouat-DenisEduardo Dei-Cas

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