PMID: 36813May 1, 1979

Pre-anesthetic cimetidine alteration of gastric fluid volume and pH

Anesthesia and Analgesia
D W CoombsT Colton


Gastric volume and pH were studied immediately after induction of anesthesia and endotracheal intubation in 101 elective surgical patients. Of 44 patients not given cimetidine, 82% had a gastric pH less than 2.5 with a mean pH of 1.6; 45% of these patients had a gastric aspirate pH less than 2.5 associated with a volume exceeding 25 ml. In 57 patients premedicated with intravenous cimetidine at variable intervals (15 to 60 minutes) prior to induction of anesthesia, a significant time-dependent increase was noted in gastric pH (p less than 0.001) together with a decline in gastric volume (p less than 0.001). Of the patients given intravenous cimetidine (mean 4.5 mg/kg) 45 minutes prior to induction of anesthesia, 90% had a gastric pH greater than 2.5. The increase in gastric pH after cimetidine administration would result in a reduced chemical pulmonary reaction should aspiration occur during induction of anesthesia.


Sep 1, 1982·Klinische Wochenschrift·G FeifelH Eissner
Jan 1, 1981·Canadian Anaesthetists' Society Journal·D W Coombs, D W Hooper
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y Mishra, I Ramzan
Jan 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y Mishra, I Ramzan
Apr 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D J Pearce
Sep 1, 1981·Canadian Anaesthetists' Society Journal·A M Lam, J A Parkin
Jan 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W J TaylorJ B Hurtig
May 1, 1986·Canadian Anaesthetists' Society Journal·R L McCammon
Mar 29, 1980·Lancet·A Gilston
Dec 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J E Royer, R G Triplett
Dec 18, 1987·The American Journal of Medicine·T H Joyce
Jan 1, 1982·Anaesthesia·J R JohnstonJ W Dundee
May 1, 1983·Anaesthesia and Intensive Care·J G Brock-UtneJ Gjessing
May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky
Nov 1, 1980·Anaesthesia and Intensive Care·P J Barnes, J H Havill

Related Concepts

Anesthesia Procedures
Inspiration Function
Gastric Juice
Hydrogen-Ion Concentration
Intubation, Intratracheal
Preanesthetic Medication

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