Pre-attentive dysfunction of musical processing in major depressive disorder: A mismatch negativity study

Journal of Affective Disorders
Zhen MuYuan Wan

Abstract

Deficits of pre-attentive information processing have been frequently found in patients with major depressive disorder, nevertheless the results are quite inconsistent due to clinical heterogeneity and methodological difference. Cognitive processing of music is a useful tool for investigating human cognition and its underlying brain mechanisms. Although general auditory processing and perception of musical sound are hampered in patients with MDD, whether the deficits in musical processing begin from pre-attentive stage is not well investigated yet. The present study aimed to investigate the MMN of musical sound in patients with MDD. MMN responses to different musical features were compared in 20 patients with MDD and 20 age-matched healthy controls. The multi-feature paradigm was used to examine automatic change detection of six different musical sound features (pitch, timbre, location, intensity, slide, rhythm) in a complex musical context. Severity of depression and co-morbid anxiety were evaluated using the Hamilton Rating Scale of Depression (HRSD-17) and the Hamilton Anxiety Rating Scale (HAMA). MMNs were obtained with all deviants. The timbre-MMN was significantly larger in MDD patients than in healthy controls, while the...Continue Reading

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Citations

Dec 16, 2016·Scientific Reports·Marina KliuchkoElvira Brattico
Aug 31, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yi-Jhan TsengChia-Hsiung Cheng

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