Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Diana S BalekianCarlos A Camargo

Abstract

Infants hospitalized for bronchiolitis (i.e. severe bronchiolitis) are at increased risk of childhood asthma. There are many known risk factors for severe bronchiolitis, including cardiac and pulmonary diseases. Less is known about the association between atopic diseases and risk of severe bronchiolitis. We sought to further examine risk factors for severe bronchiolitis, focusing on atopic dermatitis (AD). We conducted a nested cohort study within the Massachusetts General Hospital Obstetric Maternal Study (MOMS), a prospective cohort of pregnant women enrolled during 1998-2006. Children of mothers enrolled in MOMS were included in the analysis if they received care within our health system (n = 5407). Potential risk factors for bronchiolitis and hospitalization data were extracted from the children's electronic health records; we also examined pregnancy and perinatal risk factors collected from the underlying MOMS data. During the first year of life, 125 infants (2.3%) had severe bronchiolitis. Eighteen of these patients had AD; 11 (61%) were diagnosed with AD prior to bronchiolitis hospitalization. In unadjusted analyses, AD was associated with severe bronchiolitis (χ(2) 14.6; p < 0.001). In multivariable analyses adjusting f...Continue Reading

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Citations

Dec 8, 2017·Clinical and Translational Allergy·Jean BousquetIoana Agache
Nov 22, 2018·Paediatric and Perinatal Epidemiology·Christoffer DharmaUNKNOWN CHILD Study Investigators
Sep 30, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Lorena Bermúdez BarrezuetaAsunción Pino Vázquez
Jun 7, 2021·Anales De Pediatría·Lorena Bermúdez BarrezuetaAsunción Pino Vázquez

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