Pre-Clinical Investigation of a Low-Intensity Collimated Ultrasound System for Pulmonary Vein Isolation in a Porcine Model

JACC. Clinical Electrophysiology
Jacob S KoruthVivek Y Reddy

Abstract

The purpose of this study was to assess the feasibility of pulmonary vein (PV) isolation using low-intensity collimated ultrasound. Contemporary approaches to PV isolation are limited by the technical complexity of mapping and ablation. We describe a novel approach to left atrial anatomic rendering and PV isolation that aims to overcome some of these limitations by using low-intensity collimated ultrasound (LICU) system, which allows for near real-time geometry creation and automated ablation in a porcine model. Twenty swine were anesthetized, and the LICU ablation catheter was placed in the left atrium via percutaneous transseptal access. Ultrasound M-mode-based anatomies of the inferior PVs were successfully created, and ablation was performed under automatic robotic control along a user-defined lesion path. One animal was excluded because of device failure. All target PVs in the 19 remaining animals were isolated acutely, requiring a mean of 1.6 applications. Ten animals were sacrificed acutely, and the remaining 9 survived for 35 ± 11 days. Of these 9, 1 animal was excluded from analysis because the index lasso position could not be reliably recreated. PVs in 5 of 8 animals remained isolated at sacrifice. Of the 77 total hi...Continue Reading

References

Dec 12, 2002·Journal of Cardiovascular Electrophysiology·Laurent MacleMichel Haïssaguerre
Mar 31, 2007·Journal of Cardiovascular Electrophysiology·Aamir CheemaHugh Calkins
Mar 4, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vivek Y ReddyJeremy N Ruskin
May 28, 2010·Circulation. Arrhythmia and Electrophysiology·Kars NevenKarl-Heinz Kuck
Apr 20, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jacob S KoruthMoussa Mansour
Aug 30, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Karl-Heinz KuckDipen C Shah
Jul 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vivek Y ReddyKarl-Heinz Kuck
Jul 30, 2014·Journal of Cardiovascular Electrophysiology·Laura PerrottaBoris Schmidt

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Citations

Dec 13, 2019·Journal of Cardiovascular Electrophysiology·Maria TerricabrasAtul Verma
Feb 8, 2019·Toxicologic Pathology·William C StoffregenMarian K Rippy
Oct 23, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas J BuistArif Elvan

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