Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice

Restorative Neurology and Neuroscience
Hae In LeeHwa Kyoung Shin

Abstract

Transcranial low-level light therapy (LLLT) has gained interest as a non-invasive, inexpensive and safe method of modulating neurological and psychological functions in recent years. This study was designed to examine the preventive effects of LLLT via visible light source against cerebral ischemia at the behavioral, structural and neurochemical levels. The mice received LLLT twice a day for 2 days prior to photothrombotic cortical ischemia. LLLT significantly reduced infarct size and edema and improved neurological and motor function 24 h after ischemic injury. In addition, LLLT markedly inhibited Iba-1- and GFAP-positive cells, which was accompanied by a reduction in the expression of inflammatory mediators and inhibition of MAPK activation and NF-κB translocation in the ischemic cortex. Concomitantly, LLLT significantly attenuated leukocyte accumulation and infiltration into the infarct perifocal region. LLLT also prevented BBB disruption after ischemic events, as indicated by a reduction of Evans blue leakage and water content. These findings were corroborated by immunofluorescence staining of the tight junction-related proteins in the ischemic cortex in response to LLLT. Non-invasive intervention of LLLT in ischemic brain ...Continue Reading

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Citations

Jan 13, 2018·Molecular Neurobiology·Farzad SalehpourMichael R Hamblin
Mar 4, 2019·Lasers in Medical Science·Eliane Gonçalves de Jesus FonsecaIvo Ilvan Kerppers
May 5, 2018·Experimental and Therapeutic Medicine·Jia-Chen CaiYan Wang
Dec 4, 2020·Neural Regeneration Research·Muyue YangZhihui Sun

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